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Tnpo1 transportin 1 [ Mus musculus (house mouse) ]

Gene ID: 238799, updated on 9-Sep-2018

Summary

Official Symbol
Tnpo1provided by MGI
Official Full Name
transportin 1provided by MGI
Primary source
MGI:MGI:2681523
See related
Ensembl:ENSMUSG00000009470 Vega:OTTMUSG00000024774
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MIP; TRN; IPO2; MIP1; Kpnb2; AU021749; D13Ertd688e
Expression
Ubiquitous expression in CNS E11.5 (RPKM 23.2), whole brain E14.5 (RPKM 19.8) and 28 other tissues See more
Orthologs

Genomic context

See Tnpo1 in Genome Data Viewer
Location:
13 D1; 13 52.24 cM
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (98839019..98926384, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (99612036..99696339, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene FCH domain only 2 Neighboring gene predicted gene, 34995 Neighboring gene ribosomal protein S17 pseudogene Neighboring gene predicted gene 5453 Neighboring gene predicted gene, 35215 Neighboring gene RIKEN cDNA 1700024P04 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Ran GTPase binding IEA
Inferred from Electronic Annotation
more info
 
nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
ribosomal protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transportin-1
Names
importin beta-2
karyopherin (importin) beta 2
karyopherin beta-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048267.1NP_001041732.1  transportin-1 isoform 2

    See identical proteins and their annotated locations for NP_001041732.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC129085, AC154849, AK029953, AK030580
    Consensus CDS
    CCDS36760.1
    UniProtKB/Swiss-Prot
    Q8BFY9
    Related
    ENSMUSP00000105026.2, OTTMUSP00000062644, ENSMUST00000109399.8, OTTMUST00000111767
    Conserved Domains (2) summary
    COG5215
    Location:24759
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:95116
    HEAT; HEAT repeat [structural motif]
  2. NM_178716.3NP_848831.2  transportin-1 isoform 1

    See identical proteins and their annotated locations for NP_848831.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC129085, AK029953, AK030580
    Consensus CDS
    CCDS26717.2
    UniProtKB/Swiss-Prot
    Q8BFY9
    Related
    ENSMUSP00000105028.1, OTTMUSP00000029847, ENSMUST00000109401.7, OTTMUST00000061009
    Conserved Domains (2) summary
    COG5215
    Location:32767
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:103124
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

    Range
    98839019..98926384 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517636.3XP_006517699.1  transportin-1 isoform X1

    See identical proteins and their annotated locations for XP_006517699.1

    UniProtKB/Swiss-Prot
    Q8BFY9
    Conserved Domains (2) summary
    COG5215
    Location:24759
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:95116
    HEAT; HEAT repeat [structural motif]
  2. XM_006517637.3XP_006517700.1  transportin-1 isoform X1

    See identical proteins and their annotated locations for XP_006517700.1

    UniProtKB/Swiss-Prot
    Q8BFY9
    Conserved Domains (2) summary
    COG5215
    Location:24759
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:95116
    HEAT; HEAT repeat [structural motif]
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