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Ets1 E26 avian leukemia oncogene 1, 5' domain [ Mus musculus (house mouse) ]

Gene ID: 23871, updated on 18-Nov-2018

Summary

Official Symbol
Ets1provided by MGI
Official Full Name
E26 avian leukemia oncogene 1, 5' domainprovided by MGI
Primary source
MGI:MGI:95455
See related
Ensembl:ENSMUSG00000032035 Vega:OTTMUSG00000044662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
vs; Tpl1; Ets-1; AI196000; AI448617; D230050P06
Expression
Biased expression in thymus adult (RPKM 75.8), spleen adult (RPKM 42.2) and 13 other tissues See more
Orthologs

Genomic context

See Ets1 in Genome Data Viewer
Location:
9 A4; 9 17.97 cM
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (32636210..32757820)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (32503627..32565405)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31871 Neighboring gene predicted gene, 31928 Neighboring gene predicted gene 3331 Neighboring gene predicted gene 27162

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC18571, MGC130355

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific double-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
PML body organization ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell motility ISO
Inferred from Sequence Orthology
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular component movement ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to antibiotic ISO
Inferred from Sequence Orthology
more info
 
transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein C-ets-1
Names
avian erythroblastosis virus E26 oncogene 1
p54
tumor progression locus 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038642.1NP_001033731.1  protein C-ets-1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter buy has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC139108, AY035702, BB621050
    Consensus CDS
    CCDS40572.1
    UniProtKB/TrEMBL
    E9PWI8, Q8K3Q9
    Related
    ENSMUSP00000051303.6, OTTMUSP00000065698, ENSMUST00000050797.13, OTTMUST00000117492
    Conserved Domains (2) summary
    cd08542
    Location:51138
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    smart00413
    Location:247331
    ETS; erythroblast transformation specific domain
  2. NM_011808.2NP_035938.2  protein C-ets-1 isoform 1

    See identical proteins and their annotated locations for NP_035938.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC139108, AK076233, BB621050, CD550586
    Consensus CDS
    CCDS22954.1
    UniProtKB/Swiss-Prot
    P27577
    UniProtKB/TrEMBL
    Q540Q5, Q8BVW8
    Related
    ENSMUSP00000034534.5, OTTMUSP00000065695, ENSMUST00000034534.12, OTTMUST00000117489
    Conserved Domains (2) summary
    cd08542
    Location:51138
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    smart00413
    Location:334418
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    32636210..32757820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510269.1XP_006510332.1  protein C-ets-1 isoform X1

    Conserved Domains (2) summary
    cd08542
    Location:95182
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    smart00413
    Location:378462
    ETS; erythroblast transformation specific domain
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