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Ets1 E26 avian leukemia oncogene 1, 5' domain [ Mus musculus (house mouse) ]

Gene ID: 23871, updated on 3-Oct-2021

Summary

Official Symbol
Ets1provided by MGI
Official Full Name
E26 avian leukemia oncogene 1, 5' domainprovided by MGI
Primary source
MGI:MGI:95455
See related
Ensembl:ENSMUSG00000032035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tp; vs; p54; Ets-; Tpl1; Ets-1; p42Ets; p51Ets; AI196000; AI448617; D230050P06
Expression
Biased expression in thymus adult (RPKM 75.8), spleen adult (RPKM 42.2) and 13 other tissues See more
Orthologs
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Genomic context

See Ets1 in Genome Data Viewer
Location:
9 A4; 9 17.97 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (32547501..32669116)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (32636241..32757820)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (32503627..32565405)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31871 Neighboring gene predicted gene, 31928 Neighboring gene predicted gene 3331 Neighboring gene predicted gene 27162

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC18571, MGC130355

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in PML body organization ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell motility ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular component movement ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in response to antibiotic ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein C-ets-1
Names
avian erythroblastosis virus E26 oncogene 1
tumor progression locus 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038642.2NP_001033731.1  protein C-ets-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC139108
    Consensus CDS
    CCDS40572.1
    UniProtKB/TrEMBL
    E9PWI8, Q8K3Q9
    Related
    ENSMUSP00000051303.7, ENSMUST00000050797.14
    Conserved Domains (2) summary
    cd08542
    Location:51138
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    smart00413
    Location:247331
    ETS; erythroblast transformation specific domain
  2. NM_001372534.1NP_001359463.1  protein C-ets-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127581, AC139108
    Consensus CDS
    CCDS90530.1
    Related
    ENSMUSP00000159086.2, ENSMUST00000238819.2
    Conserved Domains (2) summary
    cd08542
    Location:95182
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    smart00413
    Location:378462
    ETS; erythroblast transformation specific domain
  3. NM_001372535.1NP_001359464.1  protein C-ets-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC139108
    Conserved Domains (2) summary
    cd08542
    Location:51138
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    smart00413
    Location:333417
    ETS; erythroblast transformation specific domain
  4. NM_001372536.1NP_001359465.1  protein C-ets-1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC139108
    Conserved Domains (2) summary
    pfam00178
    Location:270348
    Ets; Ets-domain
    cl15755
    Location:5168
    SAM_superfamily; SAM (Sterile alpha motif )
  5. NM_001372537.1NP_001359466.1  protein C-ets-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC139108
    Conserved Domains (2) summary
    cd08542
    Location:51138
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    smart00413
    Location:246330
    ETS; erythroblast transformation specific domain
  6. NM_011808.3NP_035938.2  protein C-ets-1 isoform 1

    See identical proteins and their annotated locations for NP_035938.2

    Status: VALIDATED

    Source sequence(s)
    AC139108
    Consensus CDS
    CCDS22954.1
    UniProtKB/Swiss-Prot
    P27577
    UniProtKB/TrEMBL
    Q540Q5, Q8BVW8
    Related
    ENSMUSP00000034534.6, ENSMUST00000034534.13
    Conserved Domains (2) summary
    cd08542
    Location:51138
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    smart00413
    Location:334418
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    32547501..32669116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154929.1XP_036010822.1  protein C-ets-1 isoform X1

    Conserved Domains (2) summary
    cd08542
    Location:95182
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    smart00413
    Location:291375
    ETS; erythroblast transformation specific domain
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