Ets1 E26 avian leukemia oncogene 1, 5' domain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ets1provided by MGI
Official Full Name: E26 avian leukemia oncogene 1, 5' domainprovided by MGI
Primary source: MGI:MGI:95455
See related: Ensembl:ENSMUSG00000032035 AllianceGenome:MGI:95455
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: vs; p54; Tpl1; Ets-1; D230050P06
Summary: Enables DNA-binding transcription factor activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of inflammatory response. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ETS1 (ETS proto-oncogene 1, transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 75.8), spleen adult (RPKM 42.2) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 17.97 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (32547501..32669116)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (32636241..32757820)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons.
Title: Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons.
ETS1 loss in mice impairs cardiac outflow tract septation via a cell migration defect autonomous to the neural crest.
Title: ETS1 loss in mice impairs cardiac outflow tract septation via a cell migration defect autonomous to the neural crest.
B Cell Activation Results in IKK-Dependent, but Not c-Rel- or RelA-Dependent, Decreases in Transcription of the B Cell Tolerance-Inducing Gene Ets1.
Title: B Cell Activation Results in IKK-Dependent, but Not c-Rel- or RelA-Dependent, Decreases in Transcription of the B Cell Tolerance-Inducing Gene Ets1.
GATA4 Regulates Developing Endocardium Through Interaction With ETS1.
Title: GATA4 Regulates Developing Endocardium Through Interaction With ETS1.
Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.
Title: Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.
Ets1 Promotes the Differentiation of Post-Selected iNKT Cells through Regulation of the Expression of Valpha14Jalpha18 T Cell Receptor and PLZF.
Title: Ets1 Promotes the Differentiation of Post-Selected iNKT Cells through Regulation of the Expression of Vα14Jα18 T Cell Receptor and PLZF.
Ets1 regulates the differentiation and function of iNKT cells through both Pointed domain-dependent and domain-independent mechanisms.
Title: Ets1 regulates the differentiation and function of iNKT cells through both Pointed domain-dependent and domain-independent mechanisms.
Gut commensals suppress interleukin-2 production through microRNA-200/BCL11B and microRNA-200/ETS-1 axes in lamina propria leukocytes of murine large intestine.
Title: Gut commensals suppress interleukin-2 production through microRNA-200/BCL11B and microRNA-200/ETS-1 axes in lamina propria leukocytes of murine large intestine.
Expression of ETS1 in gastric epithelial cells positively regulate inflammatory response in Helicobacter pylori-associated gastritis.
Title: Expression of ETS1 in gastric epithelial cells positively regulate inflammatory response in Helicobacter pylori-associated gastritis.
miR-532-3p inhibits osteogenic differentiation in MC3T3-E1 cells by downregulating ETS1.
Title: miR-532-3p inhibits osteogenic differentiation in MC3T3-E1 cells by downregulating ETS1.

Submit: New GeneRIF Correction See all GeneRIFs (113)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)
Targeted (5) 1 citation
Chemically induced (ENU) (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487501

ETS1 (e-PCR), detects polymorphism
- UniSTS:278354

RH138700 (e-PCR)
- UniSTS:220787

Ets1 (e-PCR), detects polymorphism
- UniSTS:525220

WS29 (e-PCR)
- UniSTS:677

Ets1 (e-PCR), detects polymorphism
- UniSTS:536521

AI196000 (e-PCR)
- UniSTS:165619

AI448617 (e-PCR)
- UniSTS:165620

Homology

Homologs of the Ets1 gene: The Ets1 gene is conserved in human, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 482 organisms have orthologs with human gene Ets1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	EXP Inferred from Experiment more info	PubMed
enables nucleic acid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in PML body organization	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cell motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to antibiotic	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein C-ets-1

Names: avian erythroblastosis virus E26 oncogene 1; tumor progression locus 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038642.2 → NP_001033731.1 protein C-ets-1 isoform 2

Status: VALIDATED

Source sequence(s)

AC139108

Consensus CDS

CCDS40572.1

UniProtKB/TrEMBL

A0A8C6GUI8, E9PWI8, Q8K3Q9

Related

ENSMUSP00000051303.7, ENSMUST00000050797.14

Conserved Domains (2) summary

cd08542
Location:51 → 138

SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1

smart00413
Location:247 → 331

ETS; erythroblast transformation specific domain
NM_001372534.1 → NP_001359463.1 protein C-ets-1 isoform 3

Status: VALIDATED

Source sequence(s)

AC127581, AC139108

Consensus CDS

CCDS90530.1

UniProtKB/TrEMBL

A0A5F8MPR7, A0A8C6GUM3

Related

ENSMUSP00000159086.2, ENSMUST00000238819.2

Conserved Domains (2) summary

cd08542
Location:95 → 182

SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1

smart00413
Location:378 → 462

ETS; erythroblast transformation specific domain
NM_001372535.1 → NP_001359464.1 protein C-ets-1 isoform 4

Status: VALIDATED

Source sequence(s)

AC139108

Conserved Domains (2) summary

cd08542
Location:51 → 138

SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1

smart00413
Location:333 → 417

ETS; erythroblast transformation specific domain
NM_001372536.1 → NP_001359465.1 protein C-ets-1 isoform 5

Status: VALIDATED

Source sequence(s)

AC139108

Conserved Domains (2) summary

pfam00178
Location:270 → 348

Ets; Ets-domain

cl15755
Location:51 → 68

SAM_superfamily; SAM (Sterile alpha motif )
NM_001372537.1 → NP_001359466.1 protein C-ets-1 isoform 6

Status: VALIDATED

Source sequence(s)

AC139108

Conserved Domains (2) summary

cd08542
Location:51 → 138

SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1

smart00413
Location:246 → 330

ETS; erythroblast transformation specific domain
NM_011808.3 → NP_035938.2 protein C-ets-1 isoform 1

See identical proteins and their annotated locations for NP_035938.2

Status: VALIDATED

Source sequence(s)

AC139108

Consensus CDS

CCDS22954.1

UniProtKB/Swiss-Prot

P27577, Q61403

UniProtKB/TrEMBL

A0A8C6GV01, Q540Q5, Q8BVW8

Related

ENSMUSP00000034534.6, ENSMUST00000034534.13

Conserved Domains (2) summary

cd08542
Location:51 → 138

SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1

smart00413
Location:334 → 418

ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

32547501..32669116

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154929.1 → XP_036010822.1 protein C-ets-1 isoform X1

Conserved Domains (2) summary

cd08542
Location:95 → 182

SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1

smart00413
Location:291 → 375

ETS; erythroblast transformation specific domain