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Mylk4 myosin light chain kinase family, member 4 [ Mus musculus (house mouse) ]

Gene ID: 238564, updated on 3-Apr-2024

Summary

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Official Symbol
Mylk4provided by MGI
Official Full Name
myosin light chain kinase family, member 4provided by MGI
Primary source
MGI:MGI:3643758
See related
Ensembl:ENSMUSG00000044951 AllianceGenome:MGI:3643758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG238564
Summary
Predicted to enable myosin light chain kinase activity. Orthologous to human MYLK4 (myosin light chain kinase family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 15.6), mammary gland adult (RPKM 3.8) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Mylk4 in Genome Data Viewer
Location:
13 A3.2; 13 13.72 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (32884807..32967947, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (32700824..32806773, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11381 Neighboring gene STARR-seq mESC enhancer starr_34101 Neighboring gene predicted gene, 40876 Neighboring gene Werner helicase interacting protein 1 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4. Sakakibara I, et al. iScience, 2021 Apr 23. PMID 33870126, Free PMC Article
  2. Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities. Chang AN, et al. Proc Natl Acad Sci U S A, 2016 Jul 5. PMID 27325775, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables myosin light chain kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin light chain kinase family member 4
Names
sgK085
sugen kinase 85
NP_001355809.1
NP_001413568.1
XP_006516731.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368880.1 → NP_001355809.1  myosin light chain kinase family member 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645808
    UniProtKB/TrEMBL
    A0A5F8MPR5
    Related
    ENSMUSP00000159085.3, ENSMUST00000238977.3
    Conserved Domains (1) summary
    cl21453
    Location:339 → 599
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001426639.1 → NP_001413568.1  myosin light chain kinase family member 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645808

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    32884807..32967947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516668.5 → XP_006516731.1  myosin light chain kinase family member 4 isoform X1

    UniProtKB/TrEMBL
    A0A5F8MPR5
    Conserved Domains (1) summary
    cd14193
    Location:371 → 631
    STKc_MLCK4; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001166030.1: Suppressed sequence

    Description
    NM_001166030.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SUV5.2 GenPept UniProtKB/Swiss-Prot:Q5SUV5

Gene LinkOut

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