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Dido1 death inducer-obliterator 1 [ Mus musculus (house mouse) ]

Gene ID: 23856, updated on 17-Jun-2024

Summary

Official Symbol
Dido1provided by MGI
Official Full Name
death inducer-obliterator 1provided by MGI
Primary source
MGI:MGI:1344352
See related
Ensembl:ENSMUSG00000038914 AllianceGenome:MGI:1344352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dido; DIO-1; Datf1; DATF-1; 6720461J16Rik; C130092D22Rik; D130048F08Rik
Summary
This gene encodes a transcription factor involved in apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.5), thymus adult (RPKM 4.0) and 28 other tissues See more
Orthologs
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Genomic context

See Dido1 in Genome Data Viewer
Location:
2; 2 H4
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180299757..180351886, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180657963..180710068, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene opioid growth factor receptor Neighboring gene collagen, type IX, alpha 3 Neighboring gene transcription factor-like 5 (basic helix-loop-helix) Neighboring gene predicted gene, 54097 Neighboring gene STARR-positive B cell enhancer mm9_chr2:180436639-180436940 Neighboring gene STARR-seq mESC enhancer starr_06736 Neighboring gene predicted gene, 22502 Neighboring gene STARR-positive B cell enhancer ABC_E9213 Neighboring gene GID complex subunit 8 Neighboring gene predicted gene, 30455 Neighboring gene solute carrier family 17, member 9 Neighboring gene STARR-seq mESC enhancer starr_06739 Neighboring gene STARR-positive B cell enhancer ABC_E1614 Neighboring gene basic helix-loop-helix family, member e23

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • mKIAA0333, C530043I07

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
death-inducer obliterator 1
Names
death inducer-obliterator-2
death inducer-obliterator-3
death-associated transcription factor 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291432.2NP_001278361.1  death-inducer obliterator 1 isoform Dido1

    See identical proteins and their annotated locations for NP_001278361.1

    Status: REVIEWED

    Source sequence(s)
    AL732560
    Consensus CDS
    CCDS17184.1
    UniProtKB/Swiss-Prot
    Q8C9B9
    Related
    ENSMUSP00000099344.2, ENSMUST00000103055.8
    Conserved Domains (3) summary
    cd15639
    Location:263316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam01749
    Location:165241
    IBB; Importin beta binding domain
    pfam02724
    Location:122192
    CDC45; CDC45-like protein
  2. NM_001291433.2NP_001278362.1  death-inducer obliterator 1 isoform Dido2

    See identical proteins and their annotated locations for NP_001278362.1

    Status: REVIEWED

    Source sequence(s)
    AL732560
    Consensus CDS
    CCDS17183.1
    UniProtKB/Swiss-Prot
    Q8C9B9
    Related
    ENSMUSP00000099345.4, ENSMUST00000103056.10
    Conserved Domains (4) summary
    smart00510
    Location:669770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    cd15639
    Location:263316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam01749
    Location:165241
    IBB; Importin beta binding domain
    pfam07744
    Location:10521158
    SPOC; SPOC domain
  3. NM_011805.4NP_035935.2  death-inducer obliterator 1 isoform Dido1

    See identical proteins and their annotated locations for NP_035935.2

    Status: REVIEWED

    Source sequence(s)
    AL732560
    Consensus CDS
    CCDS17184.1
    UniProtKB/Swiss-Prot
    Q8C9B9
    Related
    ENSMUSP00000119689.2, ENSMUST00000130986.8
    Conserved Domains (3) summary
    cd15639
    Location:263316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam01749
    Location:165241
    IBB; Importin beta binding domain
    pfam02724
    Location:122192
    CDC45; CDC45-like protein
  4. NM_175551.5NP_780760.2  death-inducer obliterator 1 isoform Dido3

    See identical proteins and their annotated locations for NP_780760.2

    Status: REVIEWED

    Source sequence(s)
    AL732560
    Consensus CDS
    CCDS17182.1
    UniProtKB/Swiss-Prot
    A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
    Related
    ENSMUSP00000084794.4, ENSMUST00000087517.10
    Conserved Domains (7) summary
    smart00510
    Location:669770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PRK14954
    Location:600665
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    PHA03247
    Location:15712083
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:21422180
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10451190
    SPOC; SPOC domain
  5. NM_177852.5NP_808520.2  death-inducer obliterator 1 isoform Dido2

    See identical proteins and their annotated locations for NP_808520.2

    Status: REVIEWED

    Source sequence(s)
    AL732560
    Consensus CDS
    CCDS17183.1
    UniProtKB/Swiss-Prot
    Q8C9B9
    Related
    ENSMUSP00000099346.2, ENSMUST00000103057.8
    Conserved Domains (4) summary
    smart00510
    Location:669770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    cd15639
    Location:263316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam01749
    Location:165241
    IBB; Importin beta binding domain
    pfam07744
    Location:10521158
    SPOC; SPOC domain

RNA

  1. NR_111965.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate internal exon and contains a 3' terminal exon that extends past a splice site used in variant 3. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL732560
  2. NR_169212.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL732560

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    180299757..180351886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500609.5XP_006500672.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_006500672.1

    UniProtKB/Swiss-Prot
    A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
    Conserved Domains (7) summary
    smart00510
    Location:669770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PRK14954
    Location:600665
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    PHA03247
    Location:15712083
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:21422180
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10451190
    SPOC; SPOC domain
  2. XM_006500615.5XP_006500678.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_006500678.1

    UniProtKB/Swiss-Prot
    A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
    Conserved Domains (7) summary
    smart00510
    Location:669770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PRK14954
    Location:600665
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    PHA03247
    Location:15712083
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:21422180
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10451190
    SPOC; SPOC domain
  3. XM_006500610.5XP_006500673.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_006500673.1

    UniProtKB/Swiss-Prot
    A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
    Conserved Domains (7) summary
    smart00510
    Location:669770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PRK14954
    Location:600665
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    PHA03247
    Location:15712083
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:21422180
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10451190
    SPOC; SPOC domain
  4. XM_006500608.5XP_006500671.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_006500671.1

    UniProtKB/Swiss-Prot
    A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
    Conserved Domains (7) summary
    smart00510
    Location:669770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PRK14954
    Location:600665
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    PHA03247
    Location:15712083
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:21422180
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10451190
    SPOC; SPOC domain
  5. XM_006500616.4XP_006500679.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_006500679.1

    UniProtKB/Swiss-Prot
    A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
    Conserved Domains (7) summary
    smart00510
    Location:669770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PRK14954
    Location:600665
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    PHA03247
    Location:15712083
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:21422180
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10451190
    SPOC; SPOC domain
  6. XM_006500611.5XP_006500674.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_006500674.1

    UniProtKB/Swiss-Prot
    A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
    Conserved Domains (7) summary
    smart00510
    Location:669770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PRK14954
    Location:600665
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    PHA03247
    Location:15712083
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:21422180
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10451190
    SPOC; SPOC domain
  7. XM_006500612.4XP_006500675.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_006500675.1

    UniProtKB/Swiss-Prot
    A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
    Conserved Domains (7) summary
    smart00510
    Location:669770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PRK14954
    Location:600665
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    PHA03247
    Location:15712083
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:21422180
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10451190
    SPOC; SPOC domain