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Defa17 defensin, alpha, 17 [ Mus musculus (house mouse) ]

Gene ID: 23855, updated on 2-Nov-2024

Summary

Official Symbol
Defa17provided by MGI
Official Full Name
defensin, alpha, 17provided by MGI
Primary source
MGI:MGI:1345152
See related
Ensembl:ENSMUSG00000060208 AllianceGenome:MGI:1345152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Defa3; Cryp17; Defcr3; Defcr17
Summary
Predicted to enable pore-forming activity and protein homodimerization activity. Predicted to be involved in cellular response to lipopolysaccharide; defense response to other organism; and disruption of plasma membrane integrity in another organism. Predicted to be located in midbody and secretory granule. Predicted to be active in extracellular space. Orthologous to several human genes including DEFA1 (defensin alpha 1); DEFA1B (defensin alpha 1B); and DEFA5 (defensin alpha 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in large intestine adult (RPKM 3214.7), small intestine adult (RPKM 663.1) and 1 other tissue See more
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Genomic context

See Defa17 in Genome Data Viewer
Location:
8 A2; 8 10.35 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22145783..22146752)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (21655767..21656736)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene defensin, alpha, 26 Neighboring gene STARR-seq mESC enhancer starr_20889 Neighboring gene predicted gene 15313 Neighboring gene defensin, alpha, 34 Neighboring gene STARR-seq mESC enhancer starr_20890 Neighboring gene defensin, alpha, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables pore-forming activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in disruption of plasma membrane integrity in another organism IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in innate immune response in mucosa IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-defensin 17
Names
Alpha-defensin 3
crypt defensin 17
cryptdin 17
defensin-related cryptdin-17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167790.1NP_001161262.1  alpha-defensin 17 preproprotein

    See identical proteins and their annotated locations for NP_001161262.1

    Status: VALIDATED

    Source sequence(s)
    AC134533
    Consensus CDS
    CCDS52513.1
    UniProtKB/Swiss-Prot
    P28310, P50705, P50708, Q499K7
    Related
    ENSMUSP00000078485.6, ENSMUST00000079528.6
    Conserved Domains (2) summary
    pfam00323
    Location:6492
    Defensin_1; Mammalian defensin
    pfam00879
    Location:1551
    Defensin_propep; Defensin propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    22145783..22146752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)