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Pappa2 pappalysin 2 [ Mus musculus (house mouse) ]

Gene ID: 23850, updated on 22-May-2022

Summary

Official Symbol
Pappa2provided by MGI
Official Full Name
pappalysin 2provided by MGI
Primary source
MGI:MGI:3051647
See related
Ensembl:ENSMUSG00000073530 AllianceGenome:MGI:3051647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PLAC3; Pappe; PAPP-A2
Summary
Predicted to enable metalloendopeptidase activity. Acts upstream of or within bone morphogenesis. Predicted to be located in apical plasma membrane and cytosol. Is expressed in several structures, including alimentary system; bone; genitourinary system; nervous system; and retina layer. Orthologous to human PAPPA2 (pappalysin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward placenta adult (RPKM 69.9) See more
Orthologs
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Genomic context

See Pappa2 in Genome Data Viewer
Location:
1; 1 H1
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (158539297..158788019, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (158711727..158960451, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (160641862..160887569, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1369 Neighboring gene bone morphogenic protein/retinoic acid inducible neural-specific 2 Neighboring gene astrotactin 1 Neighboring gene predicted gene, 37679 Neighboring gene microRNA 488 Neighboring gene predicted gene, 53639 Neighboring gene RIKEN cDNA 1600012P17 gene Neighboring gene predicted gene, 39687

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (5) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within bone morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pappalysin-2
Names
placenta-specific 3
pregnancy-associated plasma preproprotein-A2
pregnancy-associated plasma protein-E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085376.3NP_001078845.1  pappalysin-2 precursor

    See identical proteins and their annotated locations for NP_001078845.1

    Status: VALIDATED

    Source sequence(s)
    AC115116, AC158910, AC162173
    Consensus CDS
    CCDS48409.1
    UniProtKB/TrEMBL
    E9PZ87, Q505G3, Q8BJG6
    Related
    ENSMUSP00000124022.3, ENSMUST00000159861.9
    Conserved Domains (6) summary
    smart00004
    Location:17201756
    NL; Domain found in Notch and Lin-12
    TIGR02232
    Location:11131152
    myxo_disulf_rpt; Myxococcus cysteine-rich repeat
    cd04275
    Location:635832
    ZnMc_pappalysin_like; Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. ...
    pfam00084
    Location:15231586
    Sushi; Sushi repeat (SCR repeat)
    pfam13385
    Location:283440
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl02419
    Location:586613
    Notch; LNR domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    158539297..158788019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496824.5XP_006496887.1  pappalysin-2 isoform X1

    See identical proteins and their annotated locations for XP_006496887.1

    UniProtKB/TrEMBL
    E9PZ87
    Conserved Domains (6) summary
    smart00004
    Location:17201756
    NL; Domain found in Notch and Lin-12
    TIGR02232
    Location:11131152
    myxo_disulf_rpt; Myxococcus cysteine-rich repeat
    cd04275
    Location:635832
    ZnMc_pappalysin_like; Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. ...
    pfam00084
    Location:15231586
    Sushi; Sushi repeat (SCR repeat)
    pfam13385
    Location:283440
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl02419
    Location:586613
    Notch; LNR domain
  2. XM_036164644.1XP_036020537.1  pappalysin-2 isoform X1

    Conserved Domains (6) summary
    smart00004
    Location:17201756
    NL; Domain found in Notch and Lin-12
    TIGR02232
    Location:11131152
    myxo_disulf_rpt; Myxococcus cysteine-rich repeat
    cd04275
    Location:635832
    ZnMc_pappalysin_like; Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. ...
    pfam00084
    Location:15231586
    Sushi; Sushi repeat (SCR repeat)
    pfam13385
    Location:283440
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl02419
    Location:586613
    Notch; LNR domain