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Gpr68 G protein-coupled receptor 68 [ Mus musculus (house mouse) ]

Gene ID: 238377, updated on 13-Aug-2022

Summary

Official Symbol
Gpr68provided by MGI
Official Full Name
G protein-coupled receptor 68provided by MGI
Primary source
MGI:MGI:2441763
See related
Ensembl:ENSMUSG00000047415 AllianceGenome:MGI:2441763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ogr1
Summary
Predicted to enable G protein-coupled receptor activity. Acts upstream of or within cellular response to pH; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of myeloid leukocyte differentiation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in early conceptus; primary oocyte; and secondary oocyte. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A6. Orthologous to human GPR68 (G protein-coupled receptor 68). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 5.7), thymus adult (RPKM 5.5) and 20 other tissues See more
Orthologs
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Genomic context

See Gpr68 in Genome Data Viewer
Location:
12; 12 E
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (100842941..100874457, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (100876679..100908198, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (102114892..102146408, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40558 Neighboring gene predicted gene, 25801 Neighboring gene D-glutamate cyclase Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene predicted gene, 36572 Neighboring gene coiled-coil domain containing 88C Neighboring gene RIKEN cDNA A630072L19 gene Neighboring gene predicted gene, 36756

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ovarian cancer G-protein coupled receptor 1
Names
sphingosylphosphorylcholine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177673.1NP_001171144.1  ovarian cancer G-protein coupled receptor 1

    See identical proteins and their annotated locations for NP_001171144.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC126262, AI604270, AK036659, AK087410
    Consensus CDS
    CCDS26109.1
    UniProtKB/Swiss-Prot
    Q80T34, Q8BFQ3
    Related
    ENSMUSP00000105692.2, ENSMUST00000110065.8
    Conserved Domains (2) summary
    pfam00001
    Location:58286
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:35156
    7tm_4; Olfactory receptor
  2. NM_001177674.2NP_001171145.1  ovarian cancer G-protein coupled receptor 1

    See identical proteins and their annotated locations for NP_001171145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC126262
    Consensus CDS
    CCDS26109.1
    UniProtKB/Swiss-Prot
    Q80T34, Q8BFQ3
    Related
    ENSMUSP00000057510.4, ENSMUST00000053668.10
    Conserved Domains (2) summary
    pfam00001
    Location:58286
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:35156
    7tm_4; Olfactory receptor
  3. NM_001403314.1NP_001390243.1  ovarian cancer G-protein coupled receptor 1

    Status: VALIDATED

    Source sequence(s)
    AC126262
    UniProtKB/Swiss-Prot
    Q80T34
  4. NM_175493.4NP_780702.1  ovarian cancer G-protein coupled receptor 1

    See identical proteins and their annotated locations for NP_780702.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC126262, AI604270, AK036659
    Consensus CDS
    CCDS26109.1
    UniProtKB/Swiss-Prot
    Q80T34, Q8BFQ3
    Related
    ENSMUSP00000105693.2, ENSMUST00000110066.8
    Conserved Domains (2) summary
    pfam00001
    Location:58286
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:35156
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    100842941..100874457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315062.3XP_017170551.1  ovarian cancer G-protein coupled receptor 1 isoform X1

    Conserved Domains (1) summary
    cd15367
    Location:32307
    7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors