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Akap5 A kinase anchor protein 5 [ Mus musculus (house mouse) ]

Gene ID: 238276, updated on 27-Nov-2024

Summary

Official Symbol
Akap5provided by MGI
Official Full Name
A kinase anchor protein 5provided by MGI
Primary source
MGI:MGI:2685104
See related
Ensembl:ENSMUSG00000021057 AllianceGenome:MGI:2685104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P150; Gm258; AKAP-5; AKAP150; AKAP 150; 3526401B18Rik
Summary
Enables adenylate cyclase binding activity and molecular adaptor activity. Involved in several processes, including neuronal ion channel clustering; postsynaptic neurotransmitter receptor cycle; and synapse assembly. Acts upstream of or within several processes, including amylase secretion; cellular response to calcium ion; and cellular response to xenobiotic stimulus. Located in cytoskeleton; dendrite; and plasma membrane. Is active in postsynaptic recycling endosome. Is expressed in brain. Orthologous to human AKAP5 (A-kinase anchoring protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in lung adult (RPKM 18.7), cortex adult (RPKM 9.3) and 7 other tissues See more
Orthologs
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Genomic context

See Akap5 in Genome Data Viewer
Location:
12 C3; 12 33.73 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (76371652..76380925)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (76324617..76334517)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase Neighboring gene predicted gene, 40444 Neighboring gene predicted gene, 40443 Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene STARR-seq mESC enhancer starr_32516 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:77468237-77468545 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:77468685-77468794 Neighboring gene RIKEN cDNA 4930426I24 gene Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E94 Neighboring gene heat shock protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (8)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GABA receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables adenylate cyclase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenylate cyclase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables adenylate cyclase binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-2 adrenergic receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta-2 adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 2B binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within amylase secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to calcium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in clustering of voltage-gated calcium channels IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in clustering of voltage-gated potassium channels IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of adenylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of monoatomic ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcineurin-NFAT signaling cascade NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of calcium ion import across plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endosome to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic neurotransmitter receptor cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein-containing complex disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor clustering IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in asymmetric synapse ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite membrane ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in excitatory synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
located_in filopodium membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic recycling endosome ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein serine/threonine phosphatase complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
A-kinase anchor protein 5
Names
A kinase (PRKA) anchor protein 5
A-kinase anchor protein 150 kDa
cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101471.1NP_001094941.1  A-kinase anchor protein 5

    See identical proteins and their annotated locations for NP_001094941.1

    Status: VALIDATED

    Source sequence(s)
    AC120002
    Consensus CDS
    CCDS49092.1
    UniProtKB/Swiss-Prot
    D3YVF0, D3Z5C9
    Related
    ENSMUSP00000114495.3, ENSMUST00000154078.3
    Conserved Domains (1) summary
    pfam03832
    Location:73100
    WSK; WSK motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    76371652..76380925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515842.5XP_006515905.1  A-kinase anchor protein 5 isoform X1

    UniProtKB/TrEMBL
    H3BIV5
    Related
    ENSMUSP00000134127.2, ENSMUST00000172992.2
    Conserved Domains (1) summary
    PTZ00121
    Location:94686
    PTZ00121; MAEBL; Provisional