U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kcnh5 potassium voltage-gated channel, subfamily H (eag-related), member 5 [ Mus musculus (house mouse) ]

Gene ID: 238271, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Kcnh5provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily H (eag-related), member 5provided by MGI
Primary source
MGI:MGI:3584508
See related
Ensembl:ENSMUSG00000034402 AllianceGenome:MGI:3584508
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eag2
Summary
Predicted to enable transmembrane transporter binding activity and voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of membrane potential. Predicted to act upstream of or within regulation of G2/M transition of mitotic cell cycle. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Is expressed in several structures, including blood vessel; central nervous system; eye; genitourinary system; and thymus. Orthologous to human KCNH5 (potassium voltage-gated channel subfamily H member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 2.7), frontal lobe adult (RPKM 1.7) and 4 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Kcnh5 in Genome Data Viewer
Location:
12 C3; 12 32.62 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (74943991..75224625, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (74897217..75177332, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53728 Neighboring gene STARR-seq mESC enhancer starr_32485 Neighboring gene STARR-seq mESC enhancer starr_32486 Neighboring gene STARR-seq mESC enhancer starr_32487 Neighboring gene predicted gene, 39473 Neighboring gene STARR-seq mESC enhancer starr_32489 Neighboring gene STARR-seq mESC enhancer starr_32490 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:76492550-76492789 Neighboring gene ras homolog family member J Neighboring gene predicted gene, 34613 Neighboring gene glycoprotein hormone beta 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Divalent cations slow activation of EAG family K+ channels through direct binding to S4. Zhang X, et al. Biophys J, 2009 Jul 8. PMID 19580749, Free PMC Article
  2. Conditional gene targeting on the pure C57BL/6 genetic background. Mishina M, et al. Neurosci Res, 2007 Jun. PMID 17298852
  3. Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Huang X, et al. Genes Dev, 2012 Aug 15. PMID 22855790, Free PMC Article
  4. The transcription factor c-Maf controls touch receptor development and function. Wende H, et al. Science, 2012 Mar 16. PMID 22345400
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables delayed rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in intracellular anatomical structure ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
potassium voltage-gated channel subfamily H member 5
Names
ether-a-go-go potassium channel 2
voltage-gated potassium channel subunit Kv10.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172805.3 → NP_766393.2  potassium voltage-gated channel subfamily H member 5

    See identical proteins and their annotated locations for NP_766393.2

    Status: VALIDATED

    Source sequence(s)
    AC110175, AC131762, AK032438, CT010432
    Consensus CDS
    CCDS25980.1
    UniProtKB/Swiss-Prot
    E9QPM0, Q8C035, Q920E3
    UniProtKB/TrEMBL
    Q6NZH0
    Related
    ENSMUSP00000046864.3, ENSMUST00000042299.4
    Conserved Domains (6) summary
    COG0664
    Location:544 → 723
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:550 → 660
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:37 → 131
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:232 → 479
    Ion_trans; Ion transport protein
    pfam07885
    Location:419 → 473
    Ion_trans_2; Ion channel
    pfam08447
    Location:40 → 127
    PAS_3; PAS fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    74943991..75224625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157403.1 → XP_036013296.1  potassium voltage-gated channel subfamily H member 5 isoform X1

    Conserved Domains (2) summary
    pfam00520
    Location:217 → 479
    Ion_trans; Ion transport protein
    pfam13426
    Location:39 → 132
    PAS_9; PAS domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920E3.3 GenPept UniProtKB/Swiss-Prot:Q920E3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous