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Syt16 synaptotagmin XVI [ Mus musculus (house mouse) ]

Gene ID: 238266, updated on 24-Sep-2025
Official Symbol
Syt16provided by MGI
Official Full Name
synaptotagmin XVIprovided by MGI
Primary source
MGI:MGI:2673872
See related
Ensembl:ENSMUSG00000044912 AllianceGenome:MGI:2673872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Syt14l; syt14r; Strep14
Summary
Enables identical protein binding activity and phospholipid binding activity. Predicted to be located in membrane. Is expressed in nervous system. Orthologous to human SYT16 (synaptotagmin 16). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in CNS E18 (RPKM 19.0), cortex adult (RPKM 13.3) and 7 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Syt16 in Genome Data Viewer
Location:
12 C3; 12 32.02 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (74044490..74314690)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (73997624..74267916)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8489 Neighboring gene S100 calcium binding protein A11, pseudogene Neighboring gene small nuclear RNA activating complex, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_32482 Neighboring gene predicted gene, 40889 Neighboring gene SERTA domain containing 4B Neighboring gene DNA binding protein with his-thr domain

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans. Fukuda M. J Biochem, 2003 May. PMID 12801916
  2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Preferred Names
synaptotagmin-16
Names
synaptotagmin 14-like protein
synaptotagmin XIV-related protein

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364281.1 → NP_001351210.1  synaptotagmin-16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158365, AC161591
    Conserved Domains (2) summary
    cd08389
    Location:359 → 482
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:515 → 652
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

  2. NM_001364282.1 → NP_001351211.1  synaptotagmin-16 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158365, AC161591
    Consensus CDS
    CCDS88352.1
    UniProtKB/Swiss-Prot
    Q3UVM4, Q6PGM6, Q7TN83, Q8BJ41
    Related
    ENSMUSP00000158983.2, ENSMUST00000238790.2
    Conserved Domains (2) summary
    cd08389
    Location:344 → 467
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:500 → 637
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

  3. NM_001364283.1 → NP_001351212.1  synaptotagmin-16 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158365, AC161591
    Conserved Domains (2) summary
    cd08389
    Location:239 → 362
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:395 → 532
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

  4. NM_001364284.1 → NP_001351213.1  synaptotagmin-16 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC158365, AC161591
    Conserved Domains (2) summary
    cd08389
    Location:219 → 342
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:375 → 512
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

  5. NM_001364285.1 → NP_001351214.1  synaptotagmin-16 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC158365, AC161591
    Conserved Domains (2) summary
    cd08389
    Location:239 → 362
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cl14603
    Location:395 → 430
    C2; C2 domain

  6. NM_001422970.1 → NP_001409899.1  synaptotagmin-16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158365, AC161591

  7. NM_001422971.1 → NP_001409900.1  synaptotagmin-16 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158365, AC161591
    UniProtKB/Swiss-Prot
    Q3UVM4, Q6PGM6, Q7TN83, Q8BJ41

  8. NM_001422972.1 → NP_001409901.1  synaptotagmin-16 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158365, AC161591
    UniProtKB/Swiss-Prot
    Q3UVM4, Q6PGM6, Q7TN83, Q8BJ41

  9. NM_001422973.1 → NP_001409902.1  synaptotagmin-16 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158365, AC161591
    UniProtKB/Swiss-Prot
    Q3UVM4, Q6PGM6, Q7TN83, Q8BJ41

  10. NM_172804.3 → NP_766392.2  synaptotagmin-16 isoform 3

    See identical proteins and their annotated locations for NP_766392.2

    Status: VALIDATED

    Source sequence(s)
    AK137129, AV348245, BB074919
    Consensus CDS
    CCDS49089.1
    UniProtKB/Swiss-Prot
    Q7TN83
    Related
    ENSMUSP00000152623.2, ENSMUST00000221220.2
    Conserved Domains (2) summary
    cd08389
    Location:254 → 377
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:410 → 547
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    74044490..74314690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246702.2 → XP_030102562.1  synaptotagmin-16 isoform X1

    Conserved Domains (2) summary
    cd08389
    Location:359 → 482
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:515 → 652
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

  2. XM_036157401.1 → XP_036013294.1  synaptotagmin-16 isoform X1

    Conserved Domains (2) summary
    cd08389
    Location:359 → 482
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:515 → 652
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

  3. XM_017315058.2 → XP_017170547.1  synaptotagmin-16 isoform X1

    Conserved Domains (2) summary
    cd08389
    Location:359 → 482
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:515 → 652
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

  4. XM_036157400.1 → XP_036013293.1  synaptotagmin-16 isoform X1

    Conserved Domains (2) summary
    cd08389
    Location:359 → 482
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:515 → 652
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TN83.1 GenPept UniProtKB/Swiss-Prot:Q7TN83

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