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Dock4 dedicator of cytokinesis 4 [ Mus musculus (house mouse) ]

Gene ID: 238130, updated on 25-Sep-2020

Summary

Official Symbol
Dock4provided by MGI
Official Full Name
dedicator of cytokinesis 4provided by MGI
Primary source
MGI:MGI:1918006
See related
Ensembl:ENSMUSG00000035954
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AF263288; mKIAA0716; 5330406C03; C030023J22; 6330411N01Rik
Expression
Broad expression in cortex adult (RPKM 9.4), lung adult (RPKM 8.7) and 22 other tissues See more
Orthologs

Genomic context

See Dock4 in Genome Data Viewer
Location:
12 B1; 12 18.06 cM
Exon count:
53
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (40495956..40896873)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (40445957..40846874)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (41172640..41573082)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40403 Neighboring gene zinc finger protein 277 Neighboring gene predicted gene, 40406 Neighboring gene predicted gene, 19441 Neighboring gene SET translocation pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
Rac GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Rac guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
stereocilium IDA
Inferred from Direct Assay
more info
PubMed 
stereocilium bundle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dedicator of cytokinesis protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172803.2NP_766391.2  dedicator of cytokinesis protein 4

    See identical proteins and their annotated locations for NP_766391.2

    Status: VALIDATED

    Source sequence(s)
    AK122353, BB641326, CAAA01013241
    Consensus CDS
    CCDS25895.1
    UniProtKB/Swiss-Prot
    P59764
    Related
    ENSMUSP00000047387.6, ENSMUST00000037488.7
    Conserved Domains (4) summary
    cd08695
    Location:400584
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11705
    Location:12061596
    DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
    cd12049
    Location:1065
    SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
    pfam16172
    Location:69392
    DOCK_N; DOCK N-terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    40495956..40896873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515085.3XP_006515148.1  dedicator of cytokinesis protein 4 isoform X1

    Conserved Domains (4) summary
    cd08695
    Location:400584
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11705
    Location:12061596
    DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
    cd12049
    Location:1065
    SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
    pfam16172
    Location:69392
    DOCK_N; DOCK N-terminus
  2. XM_006515089.3XP_006515152.1  dedicator of cytokinesis protein 4 isoform X6

    Conserved Domains (4) summary
    cd08695
    Location:400584
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11705
    Location:12061596
    DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
    cd12049
    Location:1065
    SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
    pfam16172
    Location:69392
    DOCK_N; DOCK N-terminus
  3. XM_006515090.3XP_006515153.1  dedicator of cytokinesis protein 4 isoform X7

    UniProtKB/TrEMBL
    A0A1Y7VLY2
    Related
    ENSMUSP00000152420.1, ENSMUST00000220912.1
    Conserved Domains (4) summary
    cd08695
    Location:400584
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11705
    Location:12061596
    DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
    cd12049
    Location:1065
    SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
    pfam16172
    Location:69392
    DOCK_N; DOCK N-terminus
  4. XM_006515088.3XP_006515151.1  dedicator of cytokinesis protein 4 isoform X4

    Conserved Domains (4) summary
    cd08695
    Location:400584
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11705
    Location:12061596
    DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
    cd12049
    Location:1065
    SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
    pfam16172
    Location:69392
    DOCK_N; DOCK N-terminus
  5. XM_030246698.1XP_030102558.1  dedicator of cytokinesis protein 4 isoform X5

  6. XM_017315054.2XP_017170543.1  dedicator of cytokinesis protein 4 isoform X9

  7. XM_006515086.3XP_006515149.1  dedicator of cytokinesis protein 4 isoform X2

    Conserved Domains (4) summary
    cd08695
    Location:400584
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11705
    Location:11971587
    DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
    cd12049
    Location:1065
    SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
    pfam16172
    Location:69392
    DOCK_N; DOCK N-terminus
  8. XM_006515087.3XP_006515150.1  dedicator of cytokinesis protein 4 isoform X3

    Conserved Domains (4) summary
    cd08695
    Location:400584
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11705
    Location:11971587
    DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
    cd12049
    Location:1065
    SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
    pfam16172
    Location:69392
    DOCK_N; DOCK N-terminus
  9. XM_036157392.1XP_036013285.1  dedicator of cytokinesis protein 4 isoform X8

RNA

  1. XR_004937494.1 RNA Sequence

  2. XR_004937497.1 RNA Sequence

  3. XR_004937495.1 RNA Sequence

  4. XR_004937496.1 RNA Sequence

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