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Apob apolipoprotein B [ Mus musculus (house mouse) ]

Gene ID: 238055, updated on 18-Apr-2024

Summary

Official Symbol
Apobprovided by MGI
Official Full Name
apolipoprotein Bprovided by MGI
Primary source
MGI:MGI:88052
See related
Ensembl:ENSMUSG00000020609 AllianceGenome:MGI:88052
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
apob-48; apob-100; Apo B-100
Summary
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100. Unlike the apoB-48 and apoB-100 structural equivalents in human, which are synthesized exclusively in the gut and liver, respectively, the mouse apoB-48 isoform is also found in mouse liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2179 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta adult (RPKM 182.2), liver adult (RPKM 82.4) and 5 other tissues See more
Orthologs
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Genomic context

Location:
12 A1.1; 12 3.53 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (8027629..8066839)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (7977629..8016839)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene Sjogren syndrome antigen B pseudogene Neighboring gene Apob intestinal control region Neighboring gene predicted gene, 53751 Neighboring gene STARR-seq mESC enhancer starr_31489 Neighboring gene predicted gene, 33037 Neighboring gene STARR-seq mESC enhancer starr_31490 Neighboring gene STARR-seq mESC enhancer starr_31491 Neighboring gene STARR-seq mESC enhancer starr_31492 Neighboring gene STARR-positive B cell enhancer ABC_E8885 Neighboring gene lipid droplet associated hydrolase Neighboring gene STARR-seq mESC enhancer starr_31493 Neighboring gene growth differentiation factor 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (11)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC176318

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cholesterol transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables lipase binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables low-density lipoprotein particle receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within artery morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cholesterol efflux IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cholesterol homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cholesterol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment of localization in cell IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipoprotein biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lipoprotein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lipoprotein metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lipoprotein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipoprotein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lipoprotein transport IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lipoprotein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in low-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cholesterol storage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cholesterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to carbohydrate ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within triglyceride catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in triglyceride catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride mobilization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within triglyceride mobilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of chylomicron ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
part_of intermediate-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
 
part_of low-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
part_of mature chylomicron IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mature chylomicron ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of very-low-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of very-low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle lumen ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009693.2NP_033823.2  apolipoprotein B-100 precursor

    See identical proteins and their annotated locations for NP_033823.2

    Status: REVIEWED

    Source sequence(s)
    AC163900, AI324120, AK147540
    Consensus CDS
    CCDS49022.1
    UniProtKB/Swiss-Prot
    E9Q414, Q3UH74, Q497D8, Q61314, Q61318, Q8CGG8
    UniProtKB/TrEMBL
    E9Q1Y3
    Related
    ENSMUSP00000036044.7, ENSMUST00000037811.13
    Conserved Domains (4) summary
    pfam01347
    Location:46597
    Vitellogenin_N; Lipoprotein amino terminal region
    pfam06448
    Location:9611062
    DUF1081; Domain of Unknown Function (DUF1081)
    pfam09172
    Location:632944
    DUF1943; Domain of unknown function (DUF1943)
    pfam12491
    Location:44344490
    ApoB100_C; Apolipoprotein B100 C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    8027629..8066839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515078.3XP_006515141.1  apolipoprotein B-100 isoform X1

    UniProtKB/TrEMBL
    E9Q1Y3
    Conserved Domains (4) summary
    pfam06448
    Location:9601062
    DUF1081; Domain of Unknown Function (DUF1081)
    pfam09172
    Location:632937
    DUF1943; Domain of unknown function (DUF1943)
    pfam06160
    Location:20992486
    EzrA; Septation ring formation regulator, EzrA
    cl26969
    Location:46597
    Vitellogenin_N; Lipoprotein amino terminal region