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Aloxe3 arachidonate lipoxygenase 3 [ Mus musculus (house mouse) ]

Gene ID: 23801, updated on 8-May-2024

Summary

Official Symbol
Aloxe3provided by MGI
Official Full Name
arachidonate lipoxygenase 3provided by MGI
Primary source
MGI:MGI:1345140
See related
Ensembl:ENSMUSG00000020892 AllianceGenome:MGI:1345140
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
eLOX-3; e-LOX-3
Summary
Enables hepoxilin A3 synthase activity. Involved in several processes, including establishment of skin barrier; long-chain fatty acid metabolic process; and peroxisome proliferator activated receptor signaling pathway. Predicted to be located in cytoplasm. Is expressed in epidermis. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1 and autosomal recessive congenital ichthyosis 3. Orthologous to human ALOXE3 (arachidonate lipoxygenase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 6.6), CNS E18 (RPKM 2.7) and 10 other tissues See more
Orthologs
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Genomic context

See Aloxe3 in Genome Data Viewer
Location:
11 B3; 11 42.38 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69016243..69039941)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69125417..69149115)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2995 Neighboring gene nuclear encoded tRNA lysine 27 (anticodon TTT) Neighboring gene nuclear encoded tRNA glutamine 6 (anticodon CTG) Neighboring gene arachidonate 12-lipoxygenase, 12R type Neighboring gene arachidonate 8-lipoxygenase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC143829, MGC143830

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables hepoxilin A3 synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hepoxilin A3 synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hepoxilin A3 synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables hepoxilin A3 synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydroperoxy icosatetraenoate dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydroperoxy icosatetraenoate isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables intramolecular hydroxytransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in arachidonic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in bicellular tight junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ceramide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ceramide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of skin barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of skin barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in hepoxilin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hepoxilin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hepoxilin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hepoxilin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in linoleic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in linoleic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in linoleic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid oxidation IEA
Inferred from Electronic Annotation
more info
 
involved_in lipoxygenase pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipoxygenase pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in peroxisome proliferator activated receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in sphingolipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hydroperoxide isomerase ALOXE3
Names
epidermal LOX-3
epidermis-type lipoxygenase 3
hydroperoxy dehydratase ALOXE3
hydroperoxy icosatetraenoate dehydratase
hydroperoxy icosatetraenoate isomerase
NP_035916.2
XP_030101841.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011786.2NP_035916.2  hydroperoxide isomerase ALOXE3

    See identical proteins and their annotated locations for NP_035916.2

    Status: VALIDATED

    Source sequence(s)
    AK141003, AL645527, BC116259
    Consensus CDS
    CCDS24884.1
    UniProtKB/Swiss-Prot
    B1ASX3, Q9WV07
    UniProtKB/TrEMBL
    Q14B96
    Related
    ENSMUSP00000021268.3, ENSMUST00000021268.9
    Conserved Domains (2) summary
    cd01753
    Location:2116
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:268702
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69016243..69039941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245981.1XP_030101841.1  hydroperoxide isomerase ALOXE3 isoform X1

    Conserved Domains (1) summary
    pfam00305
    Location:38472
    Lipoxygenase

RNA

  1. XR_388452.5 RNA Sequence

  2. XR_004936957.1 RNA Sequence

  3. XR_004936956.1 RNA Sequence

  4. XR_003949436.1 RNA Sequence

  5. XR_004936955.1 RNA Sequence

  6. XR_388449.3 RNA Sequence

  7. XR_003949435.1 RNA Sequence

  8. XR_003949437.1 RNA Sequence