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Sdk2 sidekick cell adhesion molecule 2 [ Mus musculus (house mouse) ]

Gene ID: 237979, updated on 5-Mar-2024

Summary

Official Symbol
Sdk2provided by MGI
Official Full Name
sidekick cell adhesion molecule 2provided by MGI
Primary source
MGI:MGI:2443847
See related
Ensembl:ENSMUSG00000041592 AllianceGenome:MGI:2443847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sdk-2; mKIAA1514; 4632412F08Rik; 5330435L01Rik
Summary
Involved in homophilic cell adhesion via plasma membrane adhesion molecules; retina morphogenesis in camera-type eye; and synapse assembly. Located in synapse. Is expressed in several structures, including brain; long bone; metanephros; retina nuclear layer; and ventral grey horn. Orthologous to human SDK2 (sidekick cell adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 3.2), frontal lobe adult (RPKM 1.8) and 22 other tissues See more
Orthologs
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Genomic context

Location:
11 E2; 11 79.3 cM
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (113667200..113957855, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (113776374..114067029, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8469 Neighboring gene CDC42 effector protein 4 Neighboring gene STARR-seq mESC enhancer starr_31107 Neighboring gene VISTA enhancer mm1462 Neighboring gene predicted gene 11736 Neighboring gene predicted gene, 39468 Neighboring gene predicted gene, 51930 Neighboring gene predicted gene, 51929 Neighboring gene RIKEN cDNA 1700025D23 gene Neighboring gene RIKEN cDNA 1700001J04 gene Neighboring gene STARR-positive B cell enhancer mm9_chr11:114046847-114047148

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein sidekick-2
Names
sidekick 2
sidekick homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172800.3NP_766388.2  protein sidekick-2 precursor

    See identical proteins and their annotated locations for NP_766388.2

    Status: VALIDATED

    Source sequence(s)
    AL603706, AL627323, AL663117
    Consensus CDS
    CCDS25605.1
    UniProtKB/Swiss-Prot
    Q3TTK1, Q5U5W7, Q6V4S5, Q6ZPP2
    Related
    ENSMUSP00000038972.8, ENSMUST00000041627.14
    Conserved Domains (6) summary
    cd00096
    Location:330398
    Ig; Immunoglobulin domain
    smart00408
    Location:237290
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:506590
    IG_like; Immunoglobulin like
    cd00063
    Location:16301723
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:406496
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:420496
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    113667200..113957855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533253.5XP_006533316.1  protein sidekick-2 isoform X1

    Conserved Domains (5) summary
    cd00063
    Location:16111704
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:237290
    Ig; Immunoglobulin domain
    pfam07679
    Location:406496
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:3099
    Ig_3; Immunoglobulin domain
    cl11960
    Location:312401
    Ig; Immunoglobulin domain
  2. XM_006533255.4XP_006533318.1  protein sidekick-2 isoform X3

    Conserved Domains (4) summary
    cd00063
    Location:14721565
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:79132
    Ig; Immunoglobulin domain
    pfam07679
    Location:248338
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:154243
    Ig; Immunoglobulin domain
  3. XM_006533254.5XP_006533317.1  protein sidekick-2 isoform X2

    Conserved Domains (4) summary
    cd00063
    Location:15061599
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:113166
    Ig; Immunoglobulin domain
    pfam07679
    Location:282372
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:188277
    Ig; Immunoglobulin domain