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Aplnr apelin receptor [ Mus musculus (house mouse) ]

Gene ID: 23796, updated on 22-Nov-2021

Summary

Official Symbol
Aplnrprovided by MGI
Official Full Name
apelin receptorprovided by MGI
Primary source
MGI:MGI:1346086
See related
Ensembl:ENSMUSG00000044338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APJ; Agtrl1; msr/apj
Orthologs
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Genomic context

See Aplnr in Genome Data Viewer
Location:
2; 2 D
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84966704..84970267)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (85136360..85139923)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (84976517..84980080)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene tankyrase 1 binding protein 1 Neighboring gene RIKEN cDNA 4930443O20 gene Neighboring gene CTAGE family, member 5 pseudogene Neighboring gene uncharacterized LOC118568577

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables apelin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adult heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apelin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrioventricular valve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gastrulation IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of histone deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inhibitory G protein-coupled receptor phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of body fluid levels ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gap junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular associated smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in venous blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
apelin receptor
Names
G-protein coupled receptor APJ
MSR
angiotensin receptor-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011784.3NP_035914.1  apelin receptor

    See identical proteins and their annotated locations for NP_035914.1

    Status: VALIDATED

    Source sequence(s)
    AK133580, BY444880
    Consensus CDS
    CCDS16201.1
    UniProtKB/Swiss-Prot
    Q9WV08
    Related
    ENSMUSP00000053638.8, ENSMUST00000057019.9
    Conserved Domains (2) summary
    pfam00001
    Location:43307
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:31164
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    84966704..84970267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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