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Adamts5 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) [ Mus musculus (house mouse) ]

Gene ID: 23794, updated on 11-Jun-2019

Summary

Official Symbol
Adamts5provided by MGI
Official Full Name
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)provided by MGI
Primary source
MGI:MGI:1346321
See related
Ensembl:ENSMUSG00000022894
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADMP-2; ASMP-2; ADAMTS1; ADAM-TS5; ADAMTS11; AI481094; 9530092O11Rik
Summary
This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent aggrecanase enzyme. Mice lacking the encoded protein are protected from surgery-induced osteoarthritis and antigen-induced arthritis. [provided by RefSeq, May 2016]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 15.5), genital fat pad adult (RPKM 13.8) and 10 other tissues See more
Orthologs

Genomic context

See Adamts5 in Genome Data Viewer
Location:
16 C3.3; 16 48.34 cM
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (85858157..85901125, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (85858402..85901370, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930556C24 gene Neighboring gene a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 Neighboring gene predicted gene, 46558 Neighboring gene predicted gene, 32357 Neighboring gene predicted gene, 32461

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
extracellular matrix binding IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
defense response to bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 5
Names
aggrecanase-2
implantin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011782.2NP_035912.2  A disintegrin and metalloproteinase with thrombospondin motifs 5 preproprotein

    See identical proteins and their annotated locations for NP_035912.2

    Status: REVIEWED

    Source sequence(s)
    AC126936, AC163107, AK044746
    Consensus CDS
    CCDS28288.1
    UniProtKB/Swiss-Prot
    Q9R001
    UniProtKB/TrEMBL
    Q8BGP4
    Related
    ENSMUSP00000023611.5, ENSMUST00000023611.6
    Conserved Domains (6) summary
    smart00209
    Location:570622
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:269473
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:269476
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:68174
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:732852
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:486556
    ADAM_CR; ADAM cysteine-rich

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

    Range
    85858157..85901125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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