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Adam23 a disintegrin and metallopeptidase domain 23 [ Mus musculus (house mouse) ]

Gene ID: 23792, updated on 9-May-2024

Summary

Official Symbol
Adam23provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 23provided by MGI
Primary source
MGI:MGI:1345162
See related
Ensembl:ENSMUSG00000025964 AllianceGenome:MGI:1345162
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MDC3
Summary
This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an inactive metalloprotease and disintegrin domains. Transgenic disruption of this gene in mice results in postnatal neurological defects including tremor and ataxia resulting in death by 2 weeks of age. [provided by RefSeq, Sep 2015]
Expression
Broad expression in cerebellum adult (RPKM 24.9), cortex adult (RPKM 15.1) and 16 other tissues See more
Orthologs
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Genomic context

See Adam23 in Genome Data Viewer
Location:
1 C2; 1 32.31 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (63484880..63635263)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (63445717..63596111)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene PRELI domain containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01139 Neighboring gene STARR-seq mESC enhancer starr_01140 Neighboring gene predicted gene, 35393 Neighboring gene STARR-seq mESC enhancer starr_01141 Neighboring gene predicted gene, 22281 Neighboring gene STARR-seq mESC enhancer starr_01142 Neighboring gene family with sequence similarity 237, member A Neighboring gene dystrotelin Neighboring gene STARR-seq mESC enhancer starr_01143

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IC
Inferred by Curator
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 23
Names
a disintegrin and metalloprotease domain 23
metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011780.3NP_035910.1  disintegrin and metalloproteinase domain-containing protein 23 preproprotein

    See identical proteins and their annotated locations for NP_035910.1

    Status: REVIEWED

    Source sequence(s)
    AB009673, AK046677, AL645534, AW046396
    Consensus CDS
    CCDS14999.1
    UniProtKB/Swiss-Prot
    Q6QDY9, Q6QDZ0, Q8CC33, Q9R1V7
    Related
    ENSMUSP00000084633.4, ENSMUST00000087374.10
    Conserved Domains (5) summary
    smart00608
    Location:584723
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:296491
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:508581
    Disintegrin; Disintegrin
    pfam01421
    Location:296493
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:144246
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    63484880..63635263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495969.5XP_006496032.1  disintegrin and metalloproteinase domain-containing protein 23 isoform X1

    UniProtKB/Swiss-Prot
    Q9R1V7
    Related
    ENSMUSP00000109742.2, ENSMUST00000114107.3
    Conserved Domains (4) summary
    smart00608
    Location:584723
    ACR; ADAM Cysteine-Rich Domain
    pfam00200
    Location:508580
    Disintegrin
    pfam01421
    Location:296493
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:124246
    Pep_M12B_propep; Reprolysin family propeptide
  2. XM_006495970.5XP_006496033.1  disintegrin and metalloproteinase domain-containing protein 23 isoform X2

    UniProtKB/Swiss-Prot
    Q9R1V7
    Related
    ENSMUSP00000139862.2, ENSMUST00000114103.8
    Conserved Domains (4) summary
    smart00608
    Location:584723
    ACR; ADAM Cysteine-Rich Domain
    pfam00200
    Location:508580
    Disintegrin
    pfam01421
    Location:296493
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:124246
    Pep_M12B_propep; Reprolysin family propeptide

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001177600.1: Suppressed sequence

    Description
    NM_001177600.1: This RefSeq was removed because currently there is insufficient support for the transcript.