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Brip1 BRCA1 interacting protein C-terminal helicase 1 [ Mus musculus (house mouse) ]

Gene ID: 237911, updated on 8-Feb-2024

Summary

Official Symbol
Brip1provided by MGI
Official Full Name
BRCA1 interacting protein C-terminal helicase 1provided by MGI
Primary source
MGI:MGI:2442836
See related
Ensembl:ENSMUSG00000034329 AllianceGenome:MGI:2442836
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OF; FACJ; Bach1; Fancj; 3110009N10Rik; 8030460J03Rik
Summary
This gene encodes a member of the DEAH subfamily of DEAD box helicases. A similar protein in humans is both a DNA-dependent ATPase and a 5-prime-to-3-prime DNA helicase, and plays a role in the repair of DNA double stranded breaks through interaction with the breast cancer-associated tumor suppressor BRCA1. [provided by RefSeq, Feb 2011]
Expression
Biased expression in CNS E11.5 (RPKM 1.7), liver E14 (RPKM 1.5) and 13 other tissues See more
Orthologs
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Genomic context

See Brip1 in Genome Data Viewer
Location:
11 C; 11 51.61 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (85948957..86092041, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (86058136..86201215, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene HLEB enhancer downstream of Tbx4 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7035 Neighboring gene STARR-seq mESC enhancer starr_30261 Neighboring gene predicted gene, 20759 Neighboring gene STARR-seq mESC enhancer starr_30264 Neighboring gene STARR-positive B cell enhancer ABC_E1425 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G, pseudogene 2 Neighboring gene BRCA1 interacting protein C-terminal helicase 1, opposite strand Neighboring gene integrator complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_30265 Neighboring gene mediator complex subunit 13 Neighboring gene predicted gene, 57586

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables 5'-3' DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within chiasma assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair involved in meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within double-strand break repair involved in meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in homologous recombination NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic DNA double-strand break processing involved in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein-DNA covalent cross-linking repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within seminiferous tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogonial cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of BRCA1-B complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
Fanconi anemia group J protein homolog
Names
ATP-dependent RNA helicase BRIP1
BRCA1-associated C-terminal helicase 1
NP_840094.1
XP_036012556.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178309.2NP_840094.1  Fanconi anemia group J protein homolog

    See identical proteins and their annotated locations for NP_840094.1

    Status: REVIEWED

    Source sequence(s)
    AK051878, AK080771, BC094252, CJ240209
    Consensus CDS
    CCDS25197.1
    UniProtKB/Swiss-Prot
    Q5SXJ3, Q8BJQ8, Q8BKI6
    Related
    ENSMUSP00000043108.4, ENSMUST00000044423.4
    Conserved Domains (3) summary
    TIGR00604
    Location:248884
    rad3; DNA repair helicase (rad3)
    pfam06733
    Location:251418
    DEAD_2; DEAD_2
    pfam13307
    Location:683869
    Helicase_C_2; Helicase C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    85948957..86092041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156663.1XP_036012556.1  Fanconi anemia group J protein homolog isoform X1

    Conserved Domains (2) summary
    TIGR00604
    Location:20810
    rad3; DNA repair helicase (rad3)
    cd18788
    Location:573778
    SF2_C_XPD; C-terminal helicase domain of xeroderma pigmentosum group D (XPD) family DEAD-like helicases

RNA

  1. XR_004936951.1 RNA Sequence