Sign in to NCBI
Format

Send to:

Choose Destination

APOL2 apolipoprotein L2 [ Homo sapiens (human) ]

Gene ID: 23780, updated on 25-Nov-2021

Summary

Go to the top of the page Help
Official Symbol
APOL2provided by HGNC
Official Full Name
apolipoprotein L2provided by HGNC
Primary source
HGNC:HGNC:619
See related
Ensembl:ENSG00000128335 MIM:607252
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APOL3; APOL-II
Summary
This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 11.5), spleen (RPKM 10.5) and 25 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See APOL2 in Genome Data Viewer
Location:
22q12.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (36226209..36239954, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (36622255..36636000, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene MT-ND1 pseudogene 10 Neighboring gene apolipoprotein L4 Neighboring gene uncharacterized LOC112268296 Neighboring gene apolipoprotein L1 Neighboring gene microRNA 6819 Neighboring gene myosin heavy chain 9

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2. Luo A, et al. Neuropsychopharmacology, 2020 Jan. PMID 31466081, Free PMC Article
  2. A novel anti-apoptotic role for apolipoprotein L2 in IFN-γ-induced cytotoxicity in human bronchial epithelial cells. Liao W, et al. J Cell Physiol, 2011 Feb. PMID 20665705
  3. Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif. Ultsch M, et al. Commun Biol, 2021 Jul 27. PMID 34316015, Free PMC Article
  4. Apolipoprotein L2 contains a BH3-like domain but it does not behave as a BH3-only protein. Galindo-Moreno J, et al. Cell Death Dis, 2014 Jun 5. PMID 24901046, Free PMC Article
  5. Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia. Takahashi S, et al. Schizophr Res, 2008 Sep. PMID 18632255, Free PMC Article

See all (36) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif.
    Title: Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif.
  2. Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2.
    Title: Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2.
  3. Apolipoprotein L2 contains a BH3-like domain but it does not behave as a BH3-only protein.
    Title: Apolipoprotein L2 contains a BH3-like domain but it does not behave as a BH3-only protein.
  4. Results reveal a novel function for ApoL2 in conferring anti-apoptotic ability of human bronchial epithelium to the cytotoxic effects of IFN-gamma, in maintaining airway epithelial layer integrity.
    Title: A novel anti-apoptotic role for apolipoprotein L2 in IFN-γ-induced cytotoxicity in human bronchial epithelial cells.
  5. An association of APOL1, 2 and 4 with schizophrenia was establised.
    Title: Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
  7. APOL2 has been found only in humans and African green monkeys
    Title: The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Schizophrenia
MedGen: C0036341 OMIM: 181500 GeneReviews: Not available
Compare labs

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables high-density lipoprotein particle binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables lipid binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in acute-phase response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cholesterol metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in lipid metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in lipid transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in maternal process involved in female pregnancy NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
apolipoprotein L2
Names
apolipoprotein L, 2
apolipoprotein L-II

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023229.2 RefSeqGene

    Range
    5001..18746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030882.4 → NP_112092.2  apolipoprotein L2

    See identical proteins and their annotated locations for NP_112092.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha) is the predominant transcript. Variant alpha and variant beta encode the same protein.
    Source sequence(s)
    AF305225, AF324223, BC004395, HY306110
    Consensus CDS
    CCDS43014.1
    UniProtKB/Swiss-Prot
    Q9BQE5
    UniProtKB/TrEMBL
    A0A024R1M8
    Related
    ENSP00000351292.5, ENST00000358502.10
    Conserved Domains (1) summary
    pfam05461
    Location:33 → 331
    ApoL; Apolipoprotein L

  2. NM_145637.3 → NP_663612.2  apolipoprotein L2

    See identical proteins and their annotated locations for NP_663612.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta) differs in the 5' UTR compared to variant alpha. Both variants encode the same protein.
    Source sequence(s)
    AF305225, AF324224, BC004395, HY306110
    Consensus CDS
    CCDS43014.1
    UniProtKB/Swiss-Prot
    Q9BQE5
    UniProtKB/TrEMBL
    A0A024R1M8
    Related
    ENSP00000249066.6, ENST00000249066.10
    Conserved Domains (1) summary
    pfam05461
    Location:33 → 331
    ApoL; Apolipoprotein L

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    36226209..36239954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530075.1 → XP_011528377.1  apolipoprotein L2 isoform X1

    See identical proteins and their annotated locations for XP_011528377.1

    UniProtKB/Swiss-Prot
    Q9BQE5
    UniProtKB/TrEMBL
    A0A024R1M8
    Conserved Domains (1) summary
    pfam05461
    Location:33 → 331
    ApoL; Apolipoprotein L

  2. XM_011530074.1 → XP_011528376.1  apolipoprotein L2 isoform X1

    See identical proteins and their annotated locations for XP_011528376.1

    UniProtKB/Swiss-Prot
    Q9BQE5
    UniProtKB/TrEMBL
    A0A024R1M8
    Conserved Domains (1) summary
    pfam05461
    Location:33 → 331
    ApoL; Apolipoprotein L

  3. XM_011530078.1 → XP_011528380.1  apolipoprotein L2 isoform X1

    See identical proteins and their annotated locations for XP_011528380.1

    UniProtKB/Swiss-Prot
    Q9BQE5
    UniProtKB/TrEMBL
    A0A024R1M8
    Conserved Domains (1) summary
    pfam05461
    Location:33 → 331
    ApoL; Apolipoprotein L

  4. XM_017028724.1 → XP_016884213.1  apolipoprotein L2 isoform X2

    UniProtKB/TrEMBL
    J3KQL8
    Related
    ENSP00000403153.2, ENST00000451256.6

  5. XM_011530076.3 → XP_011528378.1  apolipoprotein L2 isoform X1

    See identical proteins and their annotated locations for XP_011528378.1

    UniProtKB/Swiss-Prot
    Q9BQE5
    UniProtKB/TrEMBL
    A0A024R1M8
    Conserved Domains (1) summary
    pfam05461
    Location:33 → 331
    ApoL; Apolipoprotein L

  6. XM_011530077.3 → XP_011528379.1  apolipoprotein L2 isoform X1

    See identical proteins and their annotated locations for XP_011528379.1

    UniProtKB/Swiss-Prot
    Q9BQE5
    UniProtKB/TrEMBL
    A0A024R1M8
    Conserved Domains (1) summary
    pfam05461
    Location:33 → 331
    ApoL; Apolipoprotein L
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BQE5.1 GenPept UniProtKB/Swiss-Prot:Q9BQE5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous
You are here: NCBI > Genes & Expression > Gene
Support Center