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APOL2 apolipoprotein L2 [ Homo sapiens (human) ]

Gene ID: 23780, updated on 5-Aug-2018

Summary

Official Symbol
APOL2provided by HGNC
Official Full Name
apolipoprotein L2provided by HGNC
Primary source
HGNC:HGNC:619
See related
Ensembl:ENSG00000128335 MIM:607252; Vega:OTTHUMG00000150634
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APOL3; APOL-II
Summary
This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 11.5), spleen (RPKM 10.5) and 25 other tissues See more
Orthologs

Genomic context

See APOL2 in Genome Data Viewer
Location:
22q12.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (36226209..36239954, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (36622255..36636000, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene MT-ND1 pseudogene 10 Neighboring gene apolipoprotein L4 Neighboring gene uncharacterized LOC112268296 Neighboring gene apolipoprotein L1 Neighboring gene microRNA 6819 Neighboring gene myosin heavy chain 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
high-density lipoprotein particle binding NAS
Non-traceable Author Statement
more info
PubMed 
lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid binding NAS
Non-traceable Author Statement
more info
PubMed 
signaling receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acute-phase response NAS
Non-traceable Author Statement
more info
PubMed 
cholesterol metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
lipid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
lipid transport NAS
Non-traceable Author Statement
more info
PubMed 
lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
 
maternal process involved in female pregnancy NAS
Non-traceable Author Statement
more info
PubMed 
multicellular organism development NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
apolipoprotein L2
Names
apolipoprotein L, 2
apolipoprotein L-II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023229.2 RefSeqGene

    Range
    5001..18746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030882.3NP_112092.2  apolipoprotein L2

    See identical proteins and their annotated locations for NP_112092.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha) is the predominant transcript. Variant alpha and variant beta encode the same protein.
    Source sequence(s)
    AF305225, AF324223, BC004395, HY306110
    Consensus CDS
    CCDS43014.1
    UniProtKB/Swiss-Prot
    Q9BQE5
    UniProtKB/TrEMBL
    A0A024R1M8
    Related
    ENSP00000351292.5, OTTHUMP00000198079, ENST00000358502.9, OTTHUMT00000319280
    Conserved Domains (1) summary
    pfam05461
    Location:33331
    ApoL; Apolipoprotein L
  2. NM_145637.2NP_663612.2  apolipoprotein L2

    See identical proteins and their annotated locations for NP_663612.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta) differs in the 5' UTR compared to variant alpha. Both variants encode the same protein.
    Source sequence(s)
    AF305225, AF324224, BC004395, HY306110
    Consensus CDS
    CCDS43014.1
    UniProtKB/Swiss-Prot
    Q9BQE5
    UniProtKB/TrEMBL
    A0A024R1M8
    Related
    ENSP00000249066.6, OTTHUMP00000198078, ENST00000249066.10, OTTHUMT00000319279
    Conserved Domains (1) summary
    pfam05461
    Location:33331
    ApoL; Apolipoprotein L

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    36226209..36239954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530075.1XP_011528377.1  apolipoprotein L2 isoform X1

    See identical proteins and their annotated locations for XP_011528377.1

    UniProtKB/Swiss-Prot
    Q9BQE5
    UniProtKB/TrEMBL
    A0A024R1M8
    Conserved Domains (1) summary
    pfam05461
    Location:33331
    ApoL; Apolipoprotein L
  2. XM_011530074.1XP_011528376.1  apolipoprotein L2 isoform X1

    See identical proteins and their annotated locations for XP_011528376.1

    UniProtKB/Swiss-Prot
    Q9BQE5
    UniProtKB/TrEMBL
    A0A024R1M8
    Conserved Domains (1) summary
    pfam05461
    Location:33331
    ApoL; Apolipoprotein L
  3. XM_011530078.1XP_011528380.1  apolipoprotein L2 isoform X1

    See identical proteins and their annotated locations for XP_011528380.1

    UniProtKB/Swiss-Prot
    Q9BQE5
    UniProtKB/TrEMBL
    A0A024R1M8
    Conserved Domains (1) summary
    pfam05461
    Location:33331
    ApoL; Apolipoprotein L
  4. XM_017028724.1XP_016884213.1  apolipoprotein L2 isoform X2

    UniProtKB/TrEMBL
    J3KQL8
    Related
    ENSP00000403153.2, OTTHUMP00000235927, ENST00000451256.6, OTTHUMT00000394590
  5. XM_011530076.3XP_011528378.1  apolipoprotein L2 isoform X1

    See identical proteins and their annotated locations for XP_011528378.1

    UniProtKB/Swiss-Prot
    Q9BQE5
    UniProtKB/TrEMBL
    A0A024R1M8
    Conserved Domains (1) summary
    pfam05461
    Location:33331
    ApoL; Apolipoprotein L
  6. XM_011530077.3XP_011528379.1  apolipoprotein L2 isoform X1

    See identical proteins and their annotated locations for XP_011528379.1

    UniProtKB/Swiss-Prot
    Q9BQE5
    UniProtKB/TrEMBL
    A0A024R1M8
    Conserved Domains (1) summary
    pfam05461
    Location:33331
    ApoL; Apolipoprotein L
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