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Fbll1 fibrillarin-like 1 [ Mus musculus (house mouse) ]

Gene ID: 237730, updated on 11-Apr-2024

Summary

Official Symbol
Fbll1provided by MGI
Official Full Name
fibrillarin-like 1provided by MGI
Primary source
MGI:MGI:3034689
See related
Ensembl:ENSMUSG00000051062 AllianceGenome:MGI:3034689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable RNA binding activity; histone-glutamine methyltransferase activity; and rRNA methyltransferase activity. Acts upstream of or within blastocyst hatching. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of box C/D RNP complex and small-subunit processome. Predicted to be active in Cajal body and nucleolus. Is expressed in early conceptus. Orthologous to human FBLL1 (fibrillarin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Fbll1 in Genome Data Viewer
Location:
11 A4; 11 21.96 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (35688207..35689711, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (35797380..35798884, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene slit guidance ligand 3 Neighboring gene predicted gene, 46278 Neighboring gene STARR-positive B cell enhancer ABC_E1137 Neighboring gene microRNA 103-1 Neighboring gene STARR-positive B cell enhancer ABC_E9361 Neighboring gene STARR-positive B cell enhancer ABC_E6965 Neighboring gene pantothenate kinase 3 Neighboring gene arginyl-tRNA synthetase 1 Neighboring gene WW, C2 and coiled-coil domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_29194

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC62475

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H2AQ104 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables rRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in box C/D sno(s)RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Cajal body IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of box C/D methylation guide snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1
Names
protein-glutamine methyltransferase
NP_001004147.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004147.3NP_001004147.1  rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1

    See identical proteins and their annotated locations for NP_001004147.1

    Status: VALIDATED

    Source sequence(s)
    BC052068, BE648485, BU701095
    Consensus CDS
    CCDS36128.1
    UniProtKB/Swiss-Prot
    Q80WS3
    Related
    ENSMUSP00000128889.2, ENSMUST00000160726.4
    Conserved Domains (1) summary
    PTZ00146
    Location:73314
    PTZ00146; fibrillarin; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    35688207..35689711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)