Fbll1 fibrillarin-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbll1provided by MGI
Official Full Name: fibrillarin-like 1provided by MGI
Primary source: MGI:MGI:3034689
See related: Ensembl:ENSMUSG00000051062 AllianceGenome:MGI:3034689
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable RNA binding activity; histone-glutamine methyltransferase activity; and rRNA methyltransferase activity. Acts upstream of or within blastocyst hatching. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of box C/D RNP complex and small-subunit processome. Predicted to be active in Cajal body and nucleolus. Is expressed in early conceptus. Orthologous to human FBLL1 (fibrillarin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 11; 11 A4

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (35688207..35689711, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (35797380..35798884, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Fbll1 gene: The Fbll1 gene is conserved in Rhesus monkey, dog, and rat.
Orthologs from Annotation Pipeline: 140 organisms have orthologs with human gene Fbll1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables histone H2AQ104 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables rRNA methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in box C/D RNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in histone glutamine methylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in rRNA methylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Cajal body	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of box C/D RNP complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1

Names: protein-glutamine methyltransferase

NP_001004147.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.