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FLRT3 fibronectin leucine rich transmembrane protein 3 [ Homo sapiens (human) ]

Gene ID: 23767, updated on 1-Aug-2020

Summary

Official Symbol
FLRT3provided by HGNC
Official Full Name
fibronectin leucine rich transmembrane protein 3provided by HGNC
Primary source
HGNC:HGNC:3762
See related
Ensembl:ENSG00000125848 MIM:604808
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HH21
Summary
This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2010]
Expression
Broad expression in kidney (RPKM 12.2), lung (RPKM 9.3) and 16 other tissues See more
Orthologs

Genomic context

See FLRT3 in Genome Data Viewer
Location:
20p12.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (14322985..14337847, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (14304639..14318313, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene mono-ADP ribosylhydrolase 2 Neighboring gene aminoacyl tRNA synthetase complex interacting multifunctional protein 1 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 864, pseudogene Neighboring gene RNA, U6 small nuclear 228, pseudogene Neighboring gene ring finger protein 11 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemorepellent activity IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging NAS
Non-traceable Author Statement
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
axon guidance IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion via plasma-membrane adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
embryonic morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
head development ISS
Inferred from Sequence or Structural Similarity
more info
 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative chemotaxis IEA
Inferred from Electronic Annotation
more info
 
neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection extension ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
proepicardium cell migration involved in pericardium morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
response to axon injury ISS
Inferred from Sequence or Structural Similarity
more info
 
synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic membrane adhesion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon terminus ISS
Inferred from Sequence or Structural Similarity
more info
 
axonal growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction IDA
Inferred from Direct Assay
more info
 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix NAS
Non-traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
growth cone membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
synaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
leucine-rich repeat transmembrane protein FLRT3
Names
fibronectin-like domain-containing leucine-rich transmembrane protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033913.1 RefSeqGene

    Range
    5056..19683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_013281.3NP_037413.1  leucine-rich repeat transmembrane protein FLRT3 precursor

    See identical proteins and their annotated locations for NP_037413.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AB040902, BC020870, DA502792
    Consensus CDS
    CCDS13121.1
    UniProtKB/Swiss-Prot
    Q9NZU0
    Related
    ENSP00000367292.3, ENST00000378053.3
    Conserved Domains (8) summary
    smart00013
    Location:3161
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:305356
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:120259
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:6184
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:85104
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:413478
    fn3; Fibronectin type III domain
    pfam12799
    Location:247287
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:247306
    LRR_8; Leucine rich repeat
  2. NM_198391.3NP_938205.1  leucine-rich repeat transmembrane protein FLRT3 precursor

    See identical proteins and their annotated locations for NP_938205.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is the longer transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AB040902, AL132826, AL529481, BC020870
    Consensus CDS
    CCDS13121.1
    UniProtKB/Swiss-Prot
    Q9NZU0
    Related
    ENSP00000339912.4, ENST00000341420.5
    Conserved Domains (8) summary
    smart00013
    Location:3161
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:305356
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:120259
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:6184
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:85104
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:413478
    fn3; Fibronectin type III domain
    pfam12799
    Location:247287
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:247306
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    14322985..14337847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529205.2XP_011527507.1  leucine-rich repeat transmembrane protein FLRT3 isoform X1

    See identical proteins and their annotated locations for XP_011527507.1

    UniProtKB/Swiss-Prot
    Q9NZU0
    Conserved Domains (8) summary
    smart00013
    Location:3161
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:305356
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:120259
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:6184
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:85104
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:413478
    fn3; Fibronectin type III domain
    pfam12799
    Location:247287
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:247306
    LRR_8; Leucine rich repeat
  2. XM_005260682.4XP_005260739.1  leucine-rich repeat transmembrane protein FLRT3 isoform X1

    See identical proteins and their annotated locations for XP_005260739.1

    UniProtKB/Swiss-Prot
    Q9NZU0
    Conserved Domains (8) summary
    smart00013
    Location:3161
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:305356
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:120259
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:6184
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:85104
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:413478
    fn3; Fibronectin type III domain
    pfam12799
    Location:247287
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:247306
    LRR_8; Leucine rich repeat
  3. XM_011529204.2XP_011527506.1  leucine-rich repeat transmembrane protein FLRT3 isoform X1

    See identical proteins and their annotated locations for XP_011527506.1

    UniProtKB/Swiss-Prot
    Q9NZU0
    Conserved Domains (8) summary
    smart00013
    Location:3161
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:305356
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:120259
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:6184
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:85104
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:413478
    fn3; Fibronectin type III domain
    pfam12799
    Location:247287
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:247306
    LRR_8; Leucine rich repeat
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