Myrfl myelin regulatory factor-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myrflprovided by MGI
Official Full Name: myelin regulatory factor-likeprovided by MGI
Primary source: MGI:MGI:2685085
See related: Ensembl:ENSMUSG00000034057 AllianceGenome:MGI:2685085
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm239
Summary: Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription, DNA-templated and protein autoprocessing. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane and nucleus. Orthologous to human MYRFL (myelin regulatory factor like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 14.9), small intestine adult (RPKM 5.9) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 10; 10 D2

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (116612450..116732784, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (116776545..116896879, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Homology

Homologs of the Myrfl gene: The Myrfl gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, C.elegans, and frog.
Orthologs from Annotation Pipeline: 464 organisms have orthologs with human gene Myrfl
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein autoprocessing	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: myelin regulatory factor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033333.3 → NP_001028505.1 myelin regulatory factor-like protein

See identical proteins and their annotated locations for NP_001028505.1

Status: PROVISIONAL

Source sequence(s)

AC123720, AC132304

Consensus CDS

CCDS36066.1

UniProtKB/Swiss-Prot

Q3UN70, Q3UN89

Related

ENSMUSP00000037477.8, ENSMUST00000048229.9

Conserved Domains (4) summary

pfam05224
Location:252 → 399

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13884
Location:446 → 504

Peptidase_S74; Chaperone of endosialidase

pfam13887
Location:525 → 549

MRF_C1; Myelin gene regulatory factor -C-terminal domain 1

pfam13888
Location:765 → 890

MRF_C2; Myelin gene regulatory factor C-terminal domain 2