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Sh3rf3 SH3 domain containing ring finger 3 [ Mus musculus (house mouse) ]

Gene ID: 237353, updated on 2-Apr-2024

Summary

Official Symbol
Sh3rf3provided by MGI
Official Full Name
SH3 domain containing ring finger 3provided by MGI
Primary source
MGI:MGI:2444637
See related
Ensembl:ENSMUSG00000037990 AllianceGenome:MGI:2444637
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sh3md4; Sh3rf31; Igfbp5-ip; 4831416G18Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of JNK cascade; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein autoubiquitination. Is expressed in several structures, including central nervous system; lung; metanephros; retina; and vibrissa. Orthologous to human SH3RF3 (SH3 domain containing ring finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 2.4), cortex adult (RPKM 1.9) and 17 other tissues See more
Orthologs
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Genomic context

See Sh3rf3 in Genome Data Viewer
Location:
10 B4; 10 29.41 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (58649181..58974738)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (58811908..59138916)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene expressed sequence BB019430 Neighboring gene STARR-seq mESC enhancer starr_26764 Neighboring gene zinc finger CCCH type containing 11A pseudogene Neighboring gene STARR-seq mESC enhancer starr_26766 Neighboring gene septin 10 Neighboring gene predicted gene, 53588 Neighboring gene predicted gene, 23223

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase SH3RF3
Names
SH3 domain-containing RING finger protein 3
SH3 multiple domains 4
SH3 multiple domains protein 4
insulin-like growth factor binding protein 5 interacting protein
plenty of SH3s 2
NP_766376.2
XP_006513680.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172788.3NP_766376.2  E3 ubiquitin-protein ligase SH3RF3

    See identical proteins and their annotated locations for NP_766376.2

    Status: VALIDATED

    Source sequence(s)
    AK133071, BC057304, BF470772, CD741846
    Consensus CDS
    CCDS35906.2
    UniProtKB/Swiss-Prot
    Q3V0K8, Q3V0Q0, Q8C120
    Related
    ENSMUSP00000120938.2, ENSMUST00000153031.2
    Conserved Domains (4) summary
    cd11785
    Location:823877
    SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
    cd11925
    Location:461517
    SH3_SH3RF3_3; Third Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
    cd00162
    Location:5193
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl17036
    Location:190243
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    58649181..58974738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513617.4XP_006513680.1  E3 ubiquitin-protein ligase SH3RF3 isoform X1

    Conserved Domains (3) summary
    cd11785
    Location:592646
    SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
    cd11925
    Location:230286
    SH3_SH3RF3_3; Third Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
    cl17036
    Location:2276
    SH3; Src Homology 3 domain superfamily