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TMEM245 transmembrane protein 245 [ Homo sapiens (human) ]

Gene ID: 23731, updated on 4-Jul-2021

Summary

Official Symbol
TMEM245provided by HGNC
Official Full Name
transmembrane protein 245provided by HGNC
Primary source
HGNC:HGNC:1363
See related
Ensembl:ENSG00000106771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CG2; CG-2; C9orf5
Expression
Ubiquitous expression in thyroid (RPKM 48.4), adrenal (RPKM 29.0) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM245 in Genome Data Viewer
Location:
9q31.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (109015135..109119963, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (111777415..111882227, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene actin binding transcription modulator Neighboring gene catenin alpha like 1 Neighboring gene uncharacterized LOC105376216 Neighboring gene RNA, 5.8S ribosomal pseudogene 3 Neighboring gene microRNA 32 Neighboring gene ferric chelate reductase 1 like Neighboring gene erythrocyte membrane protein band 4.1 like 4B Neighboring gene RNA, U6 small nuclear 984, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies.
GeneReviews: Not available
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
GeneReviews: Not available
Whole genome association scan for genetic polymorphisms influencing information processing speed.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23668, FLJ33224

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
transmembrane protein 245
Names
protein CG-2
transmembrane protein C9orf5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032012.4NP_114401.2  transmembrane protein 245

    See identical proteins and their annotated locations for NP_114401.2

    Status: VALIDATED

    Source sequence(s)
    AL354797, AL358815, AL556162, BC014248, BE675782, BM817899, BP351493, BP360669, DC341553
    Consensus CDS
    CCDS43858.1
    UniProtKB/Swiss-Prot
    Q9H330
    Related
    ENSP00000363714.3, ENST00000374586.8
    Conserved Domains (1) summary
    cl00465
    Location:594840
    AI-2E_transport; AI-2E family transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    109015135..109119963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518446.2XP_011516748.1  transmembrane protein 245 isoform X1

    Conserved Domains (1) summary
    cl00465
    Location:593839
    UPF0118; Domain of unknown function DUF20
  2. XM_011518449.2XP_011516751.1  transmembrane protein 245 isoform X4

    Conserved Domains (1) summary
    cl00465
    Location:555801
    UPF0118; Domain of unknown function DUF20
  3. XM_011518452.2XP_011516754.1  transmembrane protein 245 isoform X6

    Conserved Domains (1) summary
    cl00465
    Location:516762
    UPF0118; Domain of unknown function DUF20
  4. XM_017014572.1XP_016870061.1  transmembrane protein 245 isoform X7

  5. XM_017014571.1XP_016870060.1  transmembrane protein 245 isoform X3

  6. XM_011518451.1XP_011516753.1  transmembrane protein 245 isoform X5

    Conserved Domains (1) summary
    cl00465
    Location:551797
    UPF0118; Domain of unknown function DUF20
  7. XM_011518447.1XP_011516749.1  transmembrane protein 245 isoform X2

    Conserved Domains (1) summary
    cl00465
    Location:586832
    UPF0118; Domain of unknown function DUF20

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099734.1: Suppressed sequence

    Description
    NM_001099734.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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