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Nox1 NADPH oxidase 1 [ Mus musculus (house mouse) ]

Gene ID: 237038, updated on 25-Oct-2022

Summary

Official Symbol
Nox1provided by MGI
Official Full Name
NADPH oxidase 1provided by MGI
Primary source
MGI:MGI:2450016
See related
Ensembl:ENSMUSG00000031257 AllianceGenome:MGI:2450016
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MOX1; NOH1; NOH-1; NOX1a; Nox-1; GP91-2; NOX1alpha
Summary
This gene encodes a subunit of the NADPH oxidase enzyme, which is a membrane-bound, multisubunit protein. This complex catalyzes the transfer of electrons from NADPH to molecular oxygen to produce superoxide or hydrogen peroxide and may have a role in antimicrobial killing and cell signaling. This protein binds other subunits in order to produce superoxide. In mouse, deficiency of this enzyme may be associated with changes in blood pressure. [provided by RefSeq, Jun 2013]
Expression
Broad expression in frontal lobe adult (RPKM 2.0), cortex adult (RPKM 1.8) and 16 other tissues See more
Orthologs
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Genomic context

See Nox1 in Genome Data Viewer
Location:
X 55.69 cM; X E3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (132987170..133038455, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134086421..134137711, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 7841 Neighboring gene cleavage stimulation factor, 3' pre-RNA subunit 2 Neighboring gene microRNA 3112 Neighboring gene predicted gene, 54083 Neighboring gene X-linked Kx blood group related, X-linked Neighboring gene ADP-ribosylation factor-like 13A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD(P)H oxidase H2O2-forming activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables superoxide-generating NAD(P)H oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables superoxide-generating NAD(P)H oxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables superoxide-generating NAD(P)H oxidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to hyperoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular stress response to acidic pH ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hydrogen peroxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular pH elevation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of intrinsic apoptotic signaling pathway in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within oxygen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of integrin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of systemic arterial blood pressure by renin-angiotensin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within superoxide anion generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of NADPH oxidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NADPH oxidase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
NADPH oxidase 1
Names
GP91 phox homolog
NADH/NADPH mitogenic oxidase subunit p65-mox
NADPH oxidase 1 alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172203.2NP_757340.1  NADPH oxidase 1

    See identical proteins and their annotated locations for NP_757340.1

    Status: REVIEWED

    Source sequence(s)
    AB206383, AK136432, BY437800
    Consensus CDS
    CCDS30390.1
    UniProtKB/Swiss-Prot
    Q8CIZ9
    Related
    ENSMUSP00000033610.7, ENSMUST00000033610.13
    Conserved Domains (2) summary
    cd06186
    Location:296563
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    pfam01794
    Location:74217
    Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    132987170..133038455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528515.4XP_006528578.1  NADPH oxidase 1 isoform X1

    See identical proteins and their annotated locations for XP_006528578.1

    UniProtKB/Swiss-Prot
    Q811U2, Q8CIZ9
    Conserved Domains (2) summary
    cd06186
    Location:324591
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    pfam01794
    Location:102243
    Ferric_reduct; Ferric reductase like transmembrane component