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PPP1R15A protein phosphatase 1 regulatory subunit 15A [ Homo sapiens (human) ]

Gene ID: 23645, updated on 5-Aug-2018

Summary

Official Symbol
PPP1R15Aprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 15Aprovided by HGNC
Primary source
HGNC:HGNC:14375
See related
Ensembl:ENSG00000087074 MIM:611048; Vega:OTTHUMG00000183330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GADD34
Summary
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 214.4), gall bladder (RPKM 51.1) and 23 other tissues See more
Orthologs

Genomic context

See PPP1R15A in Genome Data Viewer
Location:
19q13.33
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (48872392..48876062)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49375649..49379319)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene hydroxysteroid 17-beta dehydrogenase 14 Neighboring gene pleckstrin homology domain containing A4 Neighboring gene tubby like protein 2 Neighboring gene nucleobindin 1 Neighboring gene NUCB1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ18408

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 1 binding IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase 1 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase activator activity IC
Inferred by Curator
more info
PubMed 
protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity IC
Inferred by Curator
more info
PubMed 
Process Evidence Code Pubs
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
cellular response to DNA damage stimulus TAS
Traceable Author Statement
more info
PubMed 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TAS
Traceable Author Statement
more info
PubMed 
negative regulation of PERK-mediated unfolded protein response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of peptidyl-serine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of translational initiation in response to stress IC
Inferred by Curator
more info
PubMed 
protein localization to endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of translational initiation by eIF2 alpha dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 1 complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 15A
Names
growth arrest and DNA damage-inducible protein GADD34
growth arrest and DNA-damage-inducible 34
myeloid differentiation primary response protein MyD116 homolog
protein phosphatase 1, regulatory (inhibitor) subunit 15A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014330.3NP_055145.3  protein phosphatase 1 regulatory subunit 15A

    See identical proteins and their annotated locations for NP_055145.3

    Status: REVIEWED

    Source sequence(s)
    AK225632, DA484808
    Consensus CDS
    CCDS12738.1
    UniProtKB/Swiss-Prot
    O75807
    Related
    ENSP00000200453.4, OTTHUMP00000271473, ENST00000200453.5, OTTHUMT00000466226
    Conserved Domains (1) summary
    pfam10488
    Location:549608
    PP1c_bdg; Phosphatase-1 catalytic subunit binding region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    48872392..48876062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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