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LDOC1 LDOC1, regulator of NFKB signaling [ Homo sapiens (human) ]

Gene ID: 23641, updated on 12-Aug-2018

Summary

Official Symbol
LDOC1provided by HGNC
Official Full Name
LDOC1, regulator of NFKB signalingprovided by HGNC
Primary source
HGNC:HGNC:6548
See related
Ensembl:ENSG00000182195 MIM:300402; Vega:OTTHUMG00000022558
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Mar7; RTL7; BCUR1; Mart7; SIRH7
Summary
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See LDOC1 in Genome Data Viewer
Location:
Xq27.1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (141175745..141177214, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (140269930..140271310, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 3, pseudogene Neighboring gene ribosomal protein L36a pseudogene Neighboring gene SPANX family member C Neighboring gene RBMX2 pseudogene 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

  • bG82i1.9,_DNA_segment_containing_(CA)_repeat (e-PCR)

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to muramyl dipeptide IMP
Inferred from Mutant Phenotype
more info
PubMed 
maternal placenta development IEA
Inferred from Electronic Annotation
more info
 
maternal process involved in parturition IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
regulation of growth hormone activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein LDOC1
Names
Sushi-Ichi retrotransposon homolog 7
breast cancer, up-regulated 1
leucine zipper down-regulated in cancer 1
leucine zipper downregulated in cancer
leucine zipper protein down-regulated in cancer cells
mammalian retrotransposon-derived 7
retrotransposon Gag like 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012317.3NP_036449.1  protein LDOC1

    See identical proteins and their annotated locations for NP_036449.1

    Status: REVIEWED

    Source sequence(s)
    AC234778
    Consensus CDS
    CCDS14672.1
    UniProtKB/Swiss-Prot
    O95751
    Related
    ENSP00000359557.2, OTTHUMP00000024174, ENST00000370526.3, OTTHUMT00000058592
    Conserved Domains (1) summary
    pfam16297
    Location:28131
    DUF4939; Domain of unknown function (DUF4939)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    141175745..141177214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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