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HSPBP1 HSPA (Hsp70) binding protein 1 [ Homo sapiens (human) ]

Gene ID: 23640, updated on 9-Dec-2018

Summary

Official Symbol
HSPBP1provided by HGNC
Official Full Name
HSPA (Hsp70) binding protein 1provided by HGNC
Primary source
HGNC:HGNC:24989
See related
Ensembl:ENSG00000133265 MIM:612939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FES1
Expression
Ubiquitous expression in brain (RPKM 7.8), kidney (RPKM 7.4) and 25 other tissues See more
Orthologs

Genomic context

See HSPBP1 in Genome Data Viewer
Location:
19q13.42
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (55262222..55280423, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55773591..55791751, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6 regulatory subunit 1 Neighboring gene microRNA 6802 Neighboring gene microRNA 6803 Neighboring gene BR serine/threonine kinase 1 Neighboring gene transmembrane protein 150B Neighboring gene lysine methyltransferase 5C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enzyme inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
hsp70-binding protein 1
Names
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
heat shock protein-binding protein 1
hsp70 interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130106.1NP_001123578.1  hsp70-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001123578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB020592, AF217996, BM853303, BU630679
    Consensus CDS
    CCDS33111.1
    UniProtKB/Swiss-Prot
    Q9NZL4
    Related
    ENSP00000255631.4, ENST00000255631.9
    Conserved Domains (2) summary
    sd00043
    Location:88130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45139
    Fes1; Nucleotide exchange factor Fes1
  2. NM_001297600.1NP_001284529.1  hsp70-binding protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longer isoform (1).
    Source sequence(s)
    AB020592, AF217996, AI859141, AK294358, DB500673
    UniProtKB/Swiss-Prot
    Q9NZL4
    Related
    ENSP00000467574.1, ENST00000587922.5
    Conserved Domains (3) summary
    cd00020
    Location:248347
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam08609
    Location:91185
    Fes1; Nucleotide exchange factor Fes1
    sd00043
    Location:134176
    ARM; armadillo repeat [structural motif]
  3. NM_012267.5NP_036399.3  hsp70-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_036399.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB020592, BM853303, BU630679
    Consensus CDS
    CCDS33111.1
    UniProtKB/Swiss-Prot
    Q9NZL4
    Related
    ENSP00000398244.1, ENST00000433386.6
    Conserved Domains (2) summary
    sd00043
    Location:88130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45139
    Fes1; Nucleotide exchange factor Fes1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    55262222..55280423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451436.1XP_024307204.1  hsp70-binding protein 1 isoform X1

    Conserved Domains (2) summary
    sd00043
    Location:88130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45139
    Fes1; Nucleotide exchange factor Fes1
  2. XM_011526691.1XP_011524993.1  hsp70-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011524993.1

    Conserved Domains (2) summary
    sd00043
    Location:88130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45139
    Fes1; Nucleotide exchange factor Fes1
  3. XM_017026543.2XP_016882032.1  hsp70-binding protein 1 isoform X1

    Conserved Domains (2) summary
    sd00043
    Location:88130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45139
    Fes1; Nucleotide exchange factor Fes1
  4. XM_005258700.2XP_005258757.1  hsp70-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005258757.1

    Conserved Domains (2) summary
    sd00043
    Location:88130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45139
    Fes1; Nucleotide exchange factor Fes1
  5. XM_017026545.1XP_016882034.1  hsp70-binding protein 1 isoform X3

  6. XM_005258701.3XP_005258758.1  hsp70-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005258758.1

    Conserved Domains (2) summary
    sd00043
    Location:88130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45139
    Fes1; Nucleotide exchange factor Fes1
  7. XM_017026544.2XP_016882033.1  hsp70-binding protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9NZL4
    Conserved Domains (2) summary
    sd00043
    Location:88130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45139
    Fes1; Nucleotide exchange factor Fes1
  8. XM_024451437.1XP_024307205.1  hsp70-binding protein 1 isoform X2

    Conserved Domains (2) summary
    sd00043
    Location:88130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45139
    Fes1; Nucleotide exchange factor Fes1
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