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HSPBP1 HSPA (Hsp70) binding protein 1 [ Homo sapiens (human) ]

Gene ID: 23640, updated on 6-Nov-2022

Summary

Official Symbol
HSPBP1provided by HGNC
Official Full Name
HSPA (Hsp70) binding protein 1provided by HGNC
Primary source
HGNC:HGNC:24989
See related
Ensembl:ENSG00000133265 MIM:612939; AllianceGenome:HGNC:24989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FES1
Summary
Enables ubiquitin protein ligase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and positive regulation of protein ubiquitination. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 7.8), kidney (RPKM 7.4) and 25 other tissues See more
Orthologs
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Genomic context

See HSPBP1 in Genome Data Viewer
Location:
19q13.42
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55262223..55280383, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58356168..58375917, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55773591..55791751, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6 regulatory subunit 1 Neighboring gene microRNA 6802 Neighboring gene microRNA 6803 Neighboring gene BR serine/threonine kinase 1 Neighboring gene transmembrane protein 150B Neighboring gene lysine methyltransferase 5C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
hsp70-binding protein 1
Names
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
heat shock protein-binding protein 1
hsp70 interacting protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130106.2NP_001123578.1  hsp70-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001123578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB020592, AF217996, BM853303, BU630679
    Consensus CDS
    CCDS33111.1
    UniProtKB/Swiss-Prot
    Q6ZNU5, Q9NZL4
    Related
    ENSP00000255631.4, ENST00000255631.9
    Conserved Domains (2) summary
    sd00043
    Location:88130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45139
    Fes1; Nucleotide exchange factor Fes1
  2. NM_001297600.2NP_001284529.1  hsp70-binding protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longer isoform (1).
    Source sequence(s)
    AB020592, AF217996, AI859141, AK294358, DB500673
    UniProtKB/Swiss-Prot
    Q9NZL4
    Related
    ENSP00000467574.1, ENST00000587922.5
    Conserved Domains (3) summary
    cd00020
    Location:248347
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam08609
    Location:91185
    Fes1; Nucleotide exchange factor Fes1
    sd00043
    Location:134176
    ARM; armadillo repeat [structural motif]
  3. NM_012267.5NP_036399.3  hsp70-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_036399.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB020592, BM853303, BU630679
    Consensus CDS
    CCDS33111.1
    UniProtKB/Swiss-Prot
    Q6ZNU5, Q9NZL4
    Related
    ENSP00000398244.1, ENST00000433386.7
    Conserved Domains (2) summary
    sd00043
    Location:88130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45139
    Fes1; Nucleotide exchange factor Fes1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    55262223..55280383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526691.2XP_011524993.1  hsp70-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011524993.1

    Conserved Domains (2) summary
    sd00043
    Location:88130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45139
    Fes1; Nucleotide exchange factor Fes1
  2. XM_024451436.2XP_024307204.1  hsp70-binding protein 1 isoform X1

    Conserved Domains (2) summary
    sd00043
    Location:88130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45139
    Fes1; Nucleotide exchange factor Fes1
  3. XM_017026544.3XP_016882033.1  hsp70-binding protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q6ZNU5, Q9NZL4
    Conserved Domains (2) summary
    sd00043
    Location:88130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45139
    Fes1; Nucleotide exchange factor Fes1
  4. XM_005258701.4XP_005258758.1  hsp70-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005258758.1

    Conserved Domains (2) summary
    sd00043
    Location:88130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45139
    Fes1; Nucleotide exchange factor Fes1
  5. XM_024451437.2XP_024307205.1  hsp70-binding protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q6ZNU5
    Conserved Domains (2) summary
    sd00043
    Location:88130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45139
    Fes1; Nucleotide exchange factor Fes1
  6. XM_017026545.2XP_016882034.1  hsp70-binding protein 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    58356168..58375917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)