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SSBP2 single stranded DNA binding protein 2 [ Homo sapiens (human) ]

Gene ID: 23635, updated on 26-Oct-2022

Summary

Official Symbol
SSBP2provided by HGNC
Official Full Name
single stranded DNA binding protein 2provided by HGNC
Primary source
HGNC:HGNC:15831
See related
Ensembl:ENSG00000145687 MIM:607389; AllianceGenome:HGNC:15831
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC116; SOSS-B2
Summary
This gene encodes a subunit of a protein complex that interacts with single-stranded DNA and is involved in the DNA damage response and maintenance of genome stability. The encoded protein may also play a role in telomere repair. A variant of this gene may be associated with survival in human glioblastoma patients. [provided by RefSeq, Sep 2016]
Expression
Ubiquitous expression in ovary (RPKM 6.2), brain (RPKM 5.5) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SSBP2 in Genome Data Viewer
Location:
5q14.1
Exon count:
29
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (81412804..81751807, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (81897401..82236409, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (80708623..81047626, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CKMT2 antisense RNA 1 Neighboring gene creatine kinase, mitochondrial 2 Neighboring gene zinc finger CCHC-type containing 9 Neighboring gene acyl-CoA thioesterase 12 Neighboring gene CRISPRi-validated cis-regulatory element chr5.2009 Neighboring gene CRISPRi-validated cis-regulatory element chr5.2010

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.
EBI GWAS Catalog
SSBP2 variants are associated with survival in glioblastoma patients.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686F03273

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables single-stranded DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
single-stranded DNA-binding protein 2
Names
sequence-specific single-stranded-DNA-binding protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051589.1 RefSeqGene

    Range
    5157..343450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256732.3NP_001243661.1  single-stranded DNA-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001243661.1

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
    Consensus CDS
    CCDS75268.1
    UniProtKB/Swiss-Prot
    P81877
    UniProtKB/TrEMBL
    A0A087X159
    Related
    ENSP00000483921.1, ENST00000615665.5
    Conserved Domains (2) summary
    smart00667
    Location:1945
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:83346
    SSDP; Single-stranded DNA binding protein, SSDP
  2. NM_001256733.3NP_001243662.1  single-stranded DNA-binding protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001243662.1

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
    Consensus CDS
    CCDS58963.1
    UniProtKB/Swiss-Prot
    P81877
    Related
    ENSP00000423969.1, ENST00000505980.5
    Conserved Domains (2) summary
    smart00667
    Location:1945
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:83318
    SSDP; Single-stranded DNA binding protein, SSDP
  3. NM_001256734.3NP_001243663.1  single-stranded DNA-binding protein 2 isoform 4

    See identical proteins and their annotated locations for NP_001243663.1

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
    Consensus CDS
    CCDS58962.1
    UniProtKB/Swiss-Prot
    P81877
    Related
    ENSP00000424657.1, ENST00000515395.5
    Conserved Domains (2) summary
    smart00667
    Location:1945
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:92316
    SSDP; Single-stranded DNA binding protein, SSDP
  4. NM_001256735.3NP_001243664.1  single-stranded DNA-binding protein 2 isoform 5

    See identical proteins and their annotated locations for NP_001243664.1

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
    Consensus CDS
    CCDS58961.1
    UniProtKB/Swiss-Prot
    P81877
    Related
    ENSP00000426183.1, ENST00000514493.5
    Conserved Domains (2) summary
    smart00667
    Location:1945
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:92308
    SSDP; Single-stranded DNA binding protein, SSDP
  5. NM_001256736.3NP_001243665.1  single-stranded DNA-binding protein 2 isoform 6

    See identical proteins and their annotated locations for NP_001243665.1

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
    Consensus CDS
    CCDS58960.1
    UniProtKB/Swiss-Prot
    P81877
    Related
    ENSP00000422961.1, ENST00000509053.5
    Conserved Domains (2) summary
    smart00667
    Location:1945
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:92297
    SSDP; Single-stranded DNA binding protein, SSDP
  6. NM_001345886.2NP_001332815.1  single-stranded DNA-binding protein 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
    Conserved Domains (2) summary
    smart00667
    Location:1945
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:83335
    SSDP; Single-stranded DNA binding protein, SSDP
  7. NM_001394350.1NP_001381279.1  single-stranded DNA-binding protein 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
    Conserved Domains (1) summary
    smart00667
    Location:1945
    LisH; Lissencephaly type-1-like homology motif
  8. NM_001394351.1NP_001381280.1  single-stranded DNA-binding protein 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
    Conserved Domains (1) summary
    pfam04503
    Location:79334
    SSDP; Single-stranded DNA binding protein, SSDP
  9. NM_001394352.1NP_001381281.1  single-stranded DNA-binding protein 2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
    Conserved Domains (2) summary
    smart00667
    Location:1945
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:83327
    SSDP; Single-stranded DNA binding protein, SSDP
  10. NM_001400340.1NP_001387269.1  single-stranded DNA-binding protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
    Consensus CDS
    CCDS75268.1
    UniProtKB/TrEMBL
    A0A087X159
  11. NM_001400341.1NP_001387270.1  single-stranded DNA-binding protein 2 11

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  12. NM_001400342.1NP_001387271.1  single-stranded DNA-binding protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
    Consensus CDS
    CCDS4056.1
    UniProtKB/Swiss-Prot
    Q9Y4T7
  13. NM_001400343.1NP_001387272.1  single-stranded DNA-binding protein 2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  14. NM_001400344.1NP_001387273.1  single-stranded DNA-binding protein 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  15. NM_001400345.1NP_001387274.1  single-stranded DNA-binding protein 2 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  16. NM_001400346.1NP_001387275.1  single-stranded DNA-binding protein 2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  17. NM_001400347.1NP_001387276.1  single-stranded DNA-binding protein 2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  18. NM_001400348.1NP_001387277.1  single-stranded DNA-binding protein 2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  19. NM_001400349.1NP_001387278.1  single-stranded DNA-binding protein 2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  20. NM_001400350.1NP_001387279.1  single-stranded DNA-binding protein 2 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC093250
  21. NM_001400351.1NP_001387280.1  single-stranded DNA-binding protein 2 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419
  22. NM_001400352.1NP_001387281.1  single-stranded DNA-binding protein 2 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  23. NM_001400353.1NP_001387282.1  single-stranded DNA-binding protein 2 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  24. NM_001400354.1NP_001387283.1  single-stranded DNA-binding protein 2 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC093250
  25. NM_001400355.1NP_001387284.1  single-stranded DNA-binding protein 2 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  26. NM_001400356.1NP_001387285.1  single-stranded DNA-binding protein 2 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  27. NM_001400357.1NP_001387286.1  single-stranded DNA-binding protein 2 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  28. NM_001400358.1NP_001387287.1  single-stranded DNA-binding protein 2 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  29. NM_001400359.1NP_001387288.1  single-stranded DNA-binding protein 2 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419
  30. NM_001400360.1NP_001387289.1  single-stranded DNA-binding protein 2 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
    Related
    ENSP00000425146.1, ENST00000504985.5
  31. NM_001400361.1NP_001387290.1  single-stranded DNA-binding protein 2 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  32. NM_001400362.1NP_001387291.1  single-stranded DNA-binding protein 2 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  33. NM_001400363.1NP_001387292.1  single-stranded DNA-binding protein 2 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
    Related
    ENSP00000424561.1, ENST00000512923.5
  34. NM_001400364.1NP_001387293.1  single-stranded DNA-binding protein 2 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419
  35. NM_001400366.1NP_001387295.1  single-stranded DNA-binding protein 2 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  36. NM_001400367.1NP_001387296.1  single-stranded DNA-binding protein 2 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  37. NM_001400368.1NP_001387297.1  single-stranded DNA-binding protein 2 isoform 34

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  38. NM_001400369.1NP_001387298.1  single-stranded DNA-binding protein 2 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  39. NM_001400371.1NP_001387300.1  single-stranded DNA-binding protein 2 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  40. NM_001400374.1NP_001387303.1  single-stranded DNA-binding protein 2 isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  41. NM_001400375.1NP_001387304.1  single-stranded DNA-binding protein 2 isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  42. NM_012446.5NP_036578.2  single-stranded DNA-binding protein 2 isoform 2

    See identical proteins and their annotated locations for NP_036578.2

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
    Consensus CDS
    CCDS4056.1
    UniProtKB/Swiss-Prot
    P81877, Q9Y4T7
    Related
    ENSP00000322977.4, ENST00000320672.9
    Conserved Domains (2) summary
    smart00667
    Location:1945
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:83338
    SSDP; Single-stranded DNA binding protein, SSDP

RNA

  1. NR_174525.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  2. NR_174526.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  3. NR_174527.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  4. NR_174528.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC093250
  5. NR_174529.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  6. NR_174530.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  7. NR_174531.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  8. NR_174532.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  9. NR_174533.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  10. NR_174534.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  11. NR_174535.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  12. NR_174536.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  13. NR_174537.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  14. NR_174538.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  15. NR_174539.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419
  16. NR_174540.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  17. NR_174541.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  18. NR_174542.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  19. NR_174543.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  20. NR_174544.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  21. NR_174545.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  22. NR_174546.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  23. NR_174547.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  24. NR_174548.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  25. NR_174549.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  26. NR_174550.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  27. NR_174551.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  28. NR_174552.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  29. NR_174553.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  30. NR_174554.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  31. NR_174555.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  32. NR_174556.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  33. NR_174557.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  34. NR_174558.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  35. NR_174559.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419
  36. NR_174560.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  37. NR_174561.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  38. NR_174562.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250
  39. NR_174563.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010623, AC016562, AC026419, AC093250

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    81412804..81751807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417066.1XP_047273022.1  single-stranded DNA-binding protein 2 isoform X5

  2. XM_047417062.1XP_047273018.1  single-stranded DNA-binding protein 2 isoform X4

  3. XM_047417061.1XP_047273017.1  single-stranded DNA-binding protein 2 isoform X3

  4. XM_047417060.1XP_047273016.1  single-stranded DNA-binding protein 2 isoform X2

  5. XM_047417058.1XP_047273014.1  single-stranded DNA-binding protein 2 isoform X1

  6. XM_047417065.1XP_047273021.1  single-stranded DNA-binding protein 2 isoform X3

  7. XM_047417059.1XP_047273015.1  single-stranded DNA-binding protein 2 isoform X1

  8. XM_017009309.2XP_016864798.1  single-stranded DNA-binding protein 2 isoform X3

    Conserved Domains (1) summary
    pfam04503
    Location:12234
    SSDP; Single-stranded DNA binding protein, SSDP
  9. XM_017009308.2XP_016864797.1  single-stranded DNA-binding protein 2 isoform X3

    Conserved Domains (1) summary
    pfam04503
    Location:12234
    SSDP; Single-stranded DNA binding protein, SSDP
  10. XM_047417064.1XP_047273020.1  single-stranded DNA-binding protein 2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    81897401..82236409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)