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KPNA6 karyopherin subunit alpha 6 [ Homo sapiens (human) ]

Gene ID: 23633, updated on 17-Jun-2019

Summary

Official Symbol
KPNA6provided by HGNC
Official Full Name
karyopherin subunit alpha 6provided by HGNC
Primary source
HGNC:HGNC:6399
See related
Ensembl:ENSG00000025800 MIM:610563
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IPOA7; KPNA7
Summary
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 11.5), brain (RPKM 9.1) and 25 other tissues See more
Orthologs

Genomic context

See KPNA6 in Genome Data Viewer
Location:
1p35.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (32108043..32176563)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32573644..32642169)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 15509 Neighboring gene transmembrane protein 39B Neighboring gene microRNA 5585 Neighboring gene taxilin alpha Neighboring gene coiled-coil domain containing 28B Neighboring gene transmembrane protein 234

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, karyopherin alpha 6 (importin alpha 7) (KPNA6), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
integrase gag-pol Some reports indicate a possible role for the interactions between karyopherin alpha and beta with HIV-1 integrase in the nuclear import of HIV-1 preintegration complexes (PIC), while other reports indicate integrase is not involved in PIC nuclear import PubMed
gag-pol Karyopherin alpha and beta are reported to interact with HIV-1 integrase (IN) to facilitate nuclear import of IN, however a conflicting report indicates nuclear accumulation of IN does not involve karyopherin alpha, beta 1, or beta 2 mediated pathways PubMed
gag-pol Karyopherin alpha binds to a bipartite nuclear localization signal in HIV-1 integrase (amino acids 186-189 and 211-219) PubMed
matrix gag Nuclear import of HIV-1 preintegration complexes by karyopherin alpha is governed by phosphorylation of HIV-1 Matrix on tyrosine and serine, however the exact role of phosphorylation of the C-terminal tyrosine of Matrix has been debated PubMed
gag HIV-1 Matrix increases intracellular ATP content, an effect hypothesized to support the ATP-dependent nuclear import of HIV-1 preintegration complexes by karyopherin alpha PubMed
gag HIV-1 Vpr increases the affinity of karyopherin alpha to the HIV-1 Matrix nuclear localization signal, thereby mediating the nuclear import of HIV-1 preintegration complexes PubMed
gag Hsp70 stimulates the binding of HIV-1 matrix to karyopherin alpha PubMed
gag The role of HIV-1 Matrix during nuclear import of the HIV-1 preintegration complex has been controversial, however recent understanding indicates HIV-1 Matrix and Vpr proteins act in concert to facilitate nuclear import by binding to karyopherin alpha PubMed
gag HIV-1 Matrix contains two nuclear localization signals (NLS) spanning amino acids 24-33 and 110-114 that are recognized by karyopherin alpha and mediate the nuclear import of HIV-1 preintegration complexes PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11249, MGC17918

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
 
nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
host cell IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
importin subunit alpha-7
Names
importin alpha 7 subunit
importin-alpha-S2
karyopherin alpha 6 (importin alpha 7)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012316.5NP_036448.1  importin subunit alpha-7

    See identical proteins and their annotated locations for NP_036448.1

    Status: REVIEWED

    Source sequence(s)
    AL049795, BC020520, BP374991
    Consensus CDS
    CCDS352.1
    UniProtKB/Swiss-Prot
    O60684
    Related
    ENSP00000362728.3, ENST00000373625.8
    Conserved Domains (2) summary
    sd00043
    Location:254279
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:36525
    Arm_3; Atypical Arm repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    32108043..32176563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446165.1XP_024301933.1  importin subunit alpha-7 isoform X2

    Conserved Domains (2) summary
    sd00043
    Location:251276
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:33522
    Arm_3; Atypical Arm repeat
  2. XM_024446167.1XP_024301935.1  importin subunit alpha-7 isoform X2

    Conserved Domains (2) summary
    sd00043
    Location:251276
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:33522
    Arm_3; Atypical Arm repeat
  3. XM_024446166.1XP_024301934.1  importin subunit alpha-7 isoform X2

    Conserved Domains (2) summary
    sd00043
    Location:251276
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:33522
    Arm_3; Atypical Arm repeat
  4. XM_005270711.3XP_005270768.1  importin subunit alpha-7 isoform X1

    See identical proteins and their annotated locations for XP_005270768.1

    Conserved Domains (5) summary
    COG5064
    Location:66555
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:281395
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01749
    Location:39132
    IBB; Importin beta binding domain
    pfam16186
    Location:494538
    Arm_3; Atypical Arm repeat
    sd00043
    Location:284309
    ARM; armadillo repeat [structural motif]
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