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PRND prion like protein doppel [ Homo sapiens (human) ]

Gene ID: 23627, updated on 21-Apr-2019

Summary

Official Symbol
PRNDprovided by HGNC
Official Full Name
prion like protein doppelprovided by HGNC
Primary source
HGNC:HGNC:15748
See related
Ensembl:ENSG00000171864 MIM:604263
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPL; PrPLP; DOPPEL; dJ1068H6.4
Summary
This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 54.6) See more
Orthologs

Genomic context

See PRND in Genome Data Viewer
Location:
20p13
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (4721854..4728462)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (4702556..4709106)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S4X pseudogene 2 Neighboring gene prion protein Neighboring gene isopentenyl-diphosphate delta isomerase 1 pseudogene Neighboring gene prion locus lncRNA, testis expressed Neighboring gene uncharacterized LOC105372511

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC41841, dJ1068H6.4,

Gene Ontology Provided by GOA

Function Evidence Code Pubs
copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acrosome reaction ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
anchored component of external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
anchored component of external side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prion-like protein doppel
Names
downstream prion protein-like
prion gene complex, downstream
prion protein 2 (dublet)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012409.4NP_036541.2  prion-like protein doppel preproprotein

    See identical proteins and their annotated locations for NP_036541.2

    Status: REVIEWED

    Source sequence(s)
    AK313404, AL133396, BC043644
    Consensus CDS
    CCDS13081.1
    UniProtKB/Swiss-Prot
    Q9UKY0
    UniProtKB/TrEMBL
    A7U7M2
    Related
    ENSP00000306900.2, ENST00000305817.3
    Conserved Domains (2) summary
    pfam00377
    Location:63163
    Prion; Prion/Doppel alpha-helical domain
    pfam11466
    Location:130
    Doppel; Prion-like protein Doppel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    4721854..4728462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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