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FAM89B family with sequence similarity 89 member B [ Homo sapiens (human) ]

Gene ID: 23625, updated on 1-Jun-2020

Summary

Official Symbol
FAM89Bprovided by HGNC
Official Full Name
family with sequence similarity 89 member Bprovided by HGNC
Primary source
HGNC:HGNC:16708
See related
Ensembl:ENSG00000176973 MIM:616128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTVR; MTVR1; LRAP25
Expression
Ubiquitous expression in ovary (RPKM 17.3), prostate (RPKM 15.4) and 25 other tissues See more
Orthologs

Genomic context

See FAM89B in Genome Data Viewer
Location:
11q13.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (65572538..65574190)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65339820..65341669)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ZNRD2 antisense RNA 1 (head to head) Neighboring gene zinc ribbon domain containing 2 Neighboring gene EH domain binding protein 1 like 1 Neighboring gene potassium two pore domain channel subfamily K member 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transcription corepressor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of SMAD protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
leucine repeat adapter protein 25
Names
leucine repeat adaptor protein 25
mammary tumor virus receptor homolog 1
protein FAM89B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098784.2NP_001092254.1  leucine repeat adapter protein 25 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region, compared to variant 1, that results in a frameshift. It encodes isoform 3 which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC032373, DR001553
    Consensus CDS
    CCDS44648.1
    UniProtKB/Swiss-Prot
    Q8N5H3
    Related
    ENSP00000402439.2, ENST00000449319.2
  2. NM_001098785.2NP_001092255.1  leucine repeat adapter protein 25 isoform 1

    See identical proteins and their annotated locations for NP_001092255.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC032373, BE394215
    Consensus CDS
    CCDS53662.1
    UniProtKB/Swiss-Prot
    Q8N5H3
    Related
    ENSP00000431459.1, ENST00000530349.2
  3. NM_152832.3NP_690045.1  leucine repeat adapter protein 25 isoform 2

    See identical proteins and their annotated locations for NP_690045.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    BC032373
    Consensus CDS
    CCDS8105.1
    UniProtKB/Swiss-Prot
    Q8N5H3
    Related
    ENSP00000314829.2, ENST00000316409.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    65572538..65574190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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