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NTSR2 neurotensin receptor 2 [ Homo sapiens (human) ]

Gene ID: 23620, updated on 1-Jun-2020

Summary

Official Symbol
NTSR2provided by HGNC
Official Full Name
neurotensin receptor 2provided by HGNC
Primary source
HGNC:HGNC:8040
See related
Ensembl:ENSG00000169006 MIM:605538
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NTR2
Summary
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 9.3) See more
Orthologs

Genomic context

See NTSR2 in Genome Data Viewer
Location:
2p25.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (11658119..11670206, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (11798304..11810329, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene growth regulating estrogen receptor binding 1 Neighboring gene RNA, 5S ribosomal pseudogene 85 Neighboring gene RNA, 7SL, cytoplasmic 674, pseudogene Neighboring gene uncharacterized LOC100506405 Neighboring gene cyclin dependent kinase 8 pseudogene 1 Neighboring gene lipin 1 Neighboring gene uncharacterized LOC101929752

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled neurotensin receptor activity IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
 
sensory perception TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neurotensin receptor type 2
Names
NT-R-2
levocabastine-sensitive neurotensin receptor
neurotensin receptor, type 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012344.4NP_036476.2  neurotensin receptor type 2

    Status: REVIEWED

    Source sequence(s)
    AC106875, AC110754
    Consensus CDS
    CCDS1681.1
    Related
    ENSP00000303686.5, ENST00000306928.6
    Conserved Domains (1) summary
    cd15356
    Location:33369
    7tmA_NTSR2; neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    11658119..11670206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711876.4XP_006711939.1  neurotensin receptor type 2 isoform X2

    Conserved Domains (1) summary
    pfam00001
    Location:98234
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_005246156.3XP_005246213.1  neurotensin receptor type 2 isoform X4

    Conserved Domains (1) summary
    pfam00001
    Location:98182
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. XM_006711877.3XP_006711940.1  neurotensin receptor type 2 isoform X3

    Conserved Domains (1) summary
    pfam00001
    Location:98234
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. XM_017003738.1XP_016859227.1  neurotensin receptor type 2 isoform X1

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