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NTSR2 neurotensin receptor 2 [ Homo sapiens (human) ]

Gene ID: 23620, updated on 23-Nov-2023

Summary

Official Symbol
NTSR2provided by HGNC
Official Full Name
neurotensin receptor 2provided by HGNC
Primary source
HGNC:HGNC:8040
See related
Ensembl:ENSG00000169006 MIM:605538; AllianceGenome:HGNC:8040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NTR2
Summary
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 9.3) See more
Orthologs
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Genomic context

See NTSR2 in Genome Data Viewer
Location:
2p25.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (11658178..11670195, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (11691322..11703339, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (11798304..11810321, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene growth regulating estrogen receptor binding 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11714607-11715107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:11718473-11719108 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:11719109-11719744 Neighboring gene RNA, 5S ribosomal pseudogene 85 Neighboring gene Sharpr-MPRA regulatory region 7562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11175 Neighboring gene RNA, 7SL, cytoplasmic 674, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:11738736-11738940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11756351-11756851 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:11771171-11772370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:11796533-11797486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11809762-11810298 Neighboring gene uncharacterized LOC100506405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11822031-11822671 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11828037-11828536 Neighboring gene cyclin dependent kinase 8 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11836720-11837568 Neighboring gene lipin 1 Neighboring gene uncharacterized LOC101929752

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
neurotensin receptor type 2
Names
NT-R-2
levocabastine-sensitive neurotensin receptor
neurotensin receptor, type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012344.4NP_036476.2  neurotensin receptor type 2

    Status: REVIEWED

    Source sequence(s)
    AC106875, AC110754
    Consensus CDS
    CCDS1681.1
    UniProtKB/Swiss-Prot
    O95665, Q53QQ5, Q57Z87, Q8IY58, Q8TBH6
    Related
    ENSP00000303686.5, ENST00000306928.6
    Conserved Domains (1) summary
    cd15356
    Location:33369
    7tmA_NTSR2; neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    11658178..11670195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246156.4XP_005246213.1  neurotensin receptor type 2 isoform X4

    Conserved Domains (1) summary
    pfam00001
    Location:98182
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_006711877.4XP_006711940.1  neurotensin receptor type 2 isoform X3

    Conserved Domains (2) summary
    cd14964
    Location:3559
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33233
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. XM_006711876.5XP_006711939.1  neurotensin receptor type 2 isoform X2

    Conserved Domains (1) summary
    pfam00001
    Location:98234
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. XM_017003738.2XP_016859227.1  neurotensin receptor type 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    11691322..11703339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341228.1XP_054197203.1  neurotensin receptor type 2 isoform X4

  2. XM_054341227.1XP_054197202.1  neurotensin receptor type 2 isoform X3

  3. XM_054341226.1XP_054197201.1  neurotensin receptor type 2 isoform X2

  4. XM_054341225.1XP_054197200.1  neurotensin receptor type 2 isoform X1