Format

Send to:

Choose Destination

TSSK2 testis specific serine kinase 2 [ Homo sapiens (human) ]

Gene ID: 23617, updated on 7-Jun-2020

Summary

Official Symbol
TSSK2provided by HGNC
Official Full Name
testis specific serine kinase 2provided by HGNC
Primary source
HGNC:HGNC:11401
See related
Ensembl:ENSG00000206203 MIM:610710
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSK2; DGS-G; SPOGA2; STK22B
Summary
TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]
Orthologs

Genomic context

See TSSK2 in Genome Data Viewer
Location:
22q11.21
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (19131308..19132622)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (19118321..19120136)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene DiGeorge syndrome critical region gene 2 Neighboring gene ribosomal protein L28 pseudogene Neighboring gene testis specific serine kinase 1A (pseudogene) Neighboring gene uncharacterized LOC112268297 Neighboring gene ess-2 splicing factor homolog Neighboring gene goosecoid homeobox 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu In vitro protein-protein interaction analysis identifies a Vpu-binding host protein testis-specific serine kinase 2 (TSSK2) PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38613

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
centriole IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
testis-specific serine/threonine-protein kinase 2
Names
TSK-2
TSSK-2
diGeorge syndrome protein G
serine/threonine kinase 22B (spermiogenesis associated)
serine/threonine-protein kinase 22B
spermiogenesis associated 2
testicular secretory protein Li 61
testis specific serine threonine kinase 2
testis-specific kinase 2
NP_443732.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053006.5NP_443732.3  testis-specific serine/threonine-protein kinase 2

    See identical proteins and their annotated locations for NP_443732.3

    Status: VALIDATED

    Source sequence(s)
    BC037781, L77564
    Consensus CDS
    CCDS13755.1
    UniProtKB/Swiss-Prot
    Q96PF2
    UniProtKB/TrEMBL
    A0ZT99
    Related
    ENSP00000382544.2, ENST00000399635.4
    Conserved Domains (2) summary
    smart00220
    Location:12272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14165
    Location:10272
    STKc_TSSK1_2-like; Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    19131308..19132622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center