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PHLDA3 pleckstrin homology like domain family A member 3 [ Homo sapiens (human) ]

Gene ID: 23612, updated on 9-Jun-2025
Official Symbol
PHLDA3provided by HGNC
Official Full Name
pleckstrin homology like domain family A member 3provided by HGNC
Primary source
HGNC:HGNC:8934
See related
Ensembl:ENSG00000174307 MIM:607054; AllianceGenome:HGNC:8934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIH1
Summary
Enables phosphatidylinositol phosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of apoptotic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Broad expression in fat (RPKM 24.2), esophagus (RPKM 11.1) and 22 other tissues See more
Orthologs
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See PHLDA3 in Genome Data Viewer
Location:
1q32.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (201464278..201469188, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (200722059..200726971, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (201433406..201438316, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929343 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2313 Neighboring gene troponin I1, slow skeletal type Neighboring gene peptidyl-prolyl cis-trans isomerase NIMA-interacting 4-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2315 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201430707-201431289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2317 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201437987-201438701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2320 Neighboring gene cysteine and glycine rich protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1692 Neighboring gene uncharacterized LOC124904484 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2321 Neighboring gene CSRP1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201487479-201487990 Neighboring gene ribosomal protein S10 pseudogene 7

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
pleckstrin homology-like domain family A member 3
Names
TDAG51/Ipl homolog 1
pleckstrin homology-like domain, family A, member 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012396.5NP_036528.1  pleckstrin homology-like domain family A member 3

    See identical proteins and their annotated locations for NP_036528.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC096677, AF151100, AI624156, BC014390, BC033874, BC068273, BE778799, BE892338, BQ000725, BX090314
    Consensus CDS
    CCDS1412.1
    UniProtKB/Swiss-Prot
    B2R5A4, Q53HD6, Q8NBW9, Q9Y5J5
    Related
    ENSP00000356280.3, ENST00000367311.5
    Conserved Domains (1) summary
    smart00233
    Location:988
    PH; Pleckstrin homology domain

RNA

  1. NR_073080.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 3' UTR. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC096677, CN356697

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    201464278..201469188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    200722059..200726971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)