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PHLDA3 pleckstrin homology like domain family A member 3 [ Homo sapiens (human) ]

Gene ID: 23612, updated on 1-Jun-2020

Summary

Official Symbol
PHLDA3provided by HGNC
Official Full Name
pleckstrin homology like domain family A member 3provided by HGNC
Primary source
HGNC:HGNC:8934
See related
Ensembl:ENSG00000174307 MIM:607054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIH1
Expression
Broad expression in fat (RPKM 24.2), esophagus (RPKM 11.1) and 22 other tissues See more
Orthologs

Genomic context

See PHLDA3 in Genome Data Viewer
Location:
1q32.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (201464278..201469188, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (201434607..201438299, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene troponin I1, slow skeletal type Neighboring gene uncharacterized LOC101929367 Neighboring gene cysteine and glycine rich protein 1 Neighboring gene uncharacterized LOC107985246 Neighboring gene ribosomal protein S10 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pleckstrin homology-like domain family A member 3
Names
TDAG51/Ipl homolog 1
pleckstrin homology-like domain, family A, member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012396.5NP_036528.1  pleckstrin homology-like domain family A member 3

    See identical proteins and their annotated locations for NP_036528.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC096677, AF151100, AI624156, BC014390, BC033874, BC068273, BE778799, BE892338, BQ000725, BX090314
    Consensus CDS
    CCDS1412.1
    UniProtKB/Swiss-Prot
    Q9Y5J5
    Related
    ENSP00000356280.3, ENST00000367311.5
    Conserved Domains (1) summary
    smart00233
    Location:988
    PH; Pleckstrin homology domain

RNA

  1. NR_073080.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 3' UTR. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC096677, CN356697

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    201464278..201469188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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