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CORO1C coronin 1C [ Homo sapiens (human) ]

Gene ID: 23603, updated on 4-Nov-2018

Summary

Official Symbol
CORO1Cprovided by HGNC
Official Full Name
coronin 1Cprovided by HGNC
Primary source
HGNC:HGNC:2254
See related
Ensembl:ENSG00000110880 MIM:605269; Vega:OTTHUMG00000169381
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCRNN4
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Expression
Ubiquitous expression in endometrium (RPKM 30.8), lung (RPKM 27.0) and 24 other tissues See more
Orthologs

Genomic context

See CORO1C in Genome Data Viewer
Location:
12q24.11
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (108645109..108759955, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109038885..109125326, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369968 Neighboring gene selectin P ligand Neighboring gene microRNA 4496 Neighboring gene RNA, U7 small nuclear 169 pseudogene Neighboring gene uncharacterized LOC105369969 Neighboring gene uncharacterized LOC101929204 Neighboring gene slingshot protein phosphatase 1 Neighboring gene microRNA 619

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rac GTPase binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
activation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase activity by regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagocytosis TAS
Traceable Author Statement
more info
PubMed 
positive regulation of lamellipodium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of epithelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of fibroblast migration ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of focal adhesion assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of ruffle assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of substrate adhesion-dependent cell spreading IGI
Inferred from Genetic Interaction
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
flotillin complex ISS
Inferred from Sequence or Structural Similarity
more info
 
focal adhesion HDA PubMed 
NOT colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
coronin-1C
Names
coronin, actin binding protein, 1C
coronin-3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105237.2NP_001098707.1  coronin-1C isoform a

    See identical proteins and their annotated locations for NP_001098707.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC007569, AM849478, BM677390
    Consensus CDS
    CCDS61236.1
    UniProtKB/Swiss-Prot
    Q9ULV4
    Related
    ENSP00000394496.2, ENST00000420959.6
    Conserved Domains (5) summary
    pfam05873
    Location:471527
    Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
    pfam08953
    Location:59116
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:396438
    WD40_4; Type of WD40 repeat
    sd00039
    Location:89131
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:128353
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001276471.1NP_001263400.1  coronin-1C isoform b

    See identical proteins and their annotated locations for NP_001263400.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate first exon and initiates translation at a downstream AUG compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC007569, AK096363, BM677390
    Consensus CDS
    CCDS9120.1
    UniProtKB/Swiss-Prot
    Q9ULV4
    UniProtKB/TrEMBL
    A0A024RBI5
    Related
    ENSP00000438341.1, OTTHUMP00000240967, ENST00000541050.5, OTTHUMT00000403803
    Conserved Domains (3) summary
    sd00039
    Location:3678
    7WD40; WD40 repeat [structural motif]
    pfam05873
    Location:418474
    Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
    cl25676
    Location:8402
    WD40_4; Type of WD40 repeat
  3. NM_014325.3NP_055140.1  coronin-1C isoform b

    See identical proteins and their annotated locations for NP_055140.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate first exon and initiates translation at a downstream AUG compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AB030656, AC007569, BM677390, DB450956
    Consensus CDS
    CCDS9120.1
    UniProtKB/Swiss-Prot
    Q9ULV4
    UniProtKB/TrEMBL
    A0A024RBI5
    Related
    ENSP00000261401.3, OTTHUMP00000240966, ENST00000261401.7, OTTHUMT00000403802
    Conserved Domains (3) summary
    sd00039
    Location:3678
    7WD40; WD40 repeat [structural motif]
    pfam05873
    Location:418474
    Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
    cl25676
    Location:8402
    WD40_4; Type of WD40 repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    108645109..108759955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448916.1XP_024304684.1  coronin-1C isoform X1

    Conserved Domains (3) summary
    sd00039
    Location:3678
    7WD40; WD40 repeat [structural motif]
    pfam05873
    Location:418474
    Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
    cl25676
    Location:8402
    WD40_4; Type of WD40 repeat
  2. XM_024448915.1XP_024304683.1  coronin-1C isoform X1

    Conserved Domains (3) summary
    sd00039
    Location:3678
    7WD40; WD40 repeat [structural motif]
    pfam05873
    Location:418474
    Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
    cl25676
    Location:8402
    WD40_4; Type of WD40 repeat
  3. XM_017019122.2XP_016874611.1  coronin-1C isoform X1

    UniProtKB/Swiss-Prot
    Q9ULV4
    UniProtKB/TrEMBL
    A0A024RBI5
    Conserved Domains (3) summary
    sd00039
    Location:3678
    7WD40; WD40 repeat [structural motif]
    pfam05873
    Location:418474
    Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
    cl25676
    Location:8402
    WD40_4; Type of WD40 repeat
  4. XM_017019121.2XP_016874610.1  coronin-1C isoform X2

    UniProtKB/Swiss-Prot
    Q9ULV4
    Conserved Domains (5) summary
    pfam05873
    Location:471527
    Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
    pfam08953
    Location:59116
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:396438
    WD40_4; Type of WD40 repeat
    sd00039
    Location:89131
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:128353
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_017019123.2XP_016874612.1  coronin-1C isoform X1

    UniProtKB/Swiss-Prot
    Q9ULV4
    UniProtKB/TrEMBL
    A0A024RBI5
    Conserved Domains (3) summary
    sd00039
    Location:3678
    7WD40; WD40 repeat [structural motif]
    pfam05873
    Location:418474
    Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
    cl25676
    Location:8402
    WD40_4; Type of WD40 repeat
  6. XM_024448914.1XP_024304682.1  coronin-1C isoform X1

    Conserved Domains (3) summary
    sd00039
    Location:3678
    7WD40; WD40 repeat [structural motif]
    pfam05873
    Location:418474
    Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
    cl25676
    Location:8402
    WD40_4; Type of WD40 repeat
  7. XM_011538125.1XP_011536427.1  coronin-1C isoform X4

    Conserved Domains (2) summary
    pfam05873
    Location:230286
    Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
    pfam16300
    Location:155197
    WD40_4; Type of WD40 repeat
  8. XM_024448917.1XP_024304685.1  coronin-1C isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:89131
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:61354
    WD40_4; Type of WD40 repeat

RNA

  1. XR_944514.2 RNA Sequence

  2. XR_001748650.1 RNA Sequence

  3. XR_002957304.1 RNA Sequence

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