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ACOT9 acyl-CoA thioesterase 9 [ Homo sapiens (human) ]

Gene ID: 23597, updated on 21-Apr-2019

Summary

Official Symbol
ACOT9provided by HGNC
Official Full Name
acyl-CoA thioesterase 9provided by HGNC
Primary source
HGNC:HGNC:17152
See related
Ensembl:ENSG00000123130 MIM:300862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACATE2; CGI-16; MTACT48; MT-ACT48
Summary
The protein encoded by this gene is a mitochondrial acyl-CoA thioesterase of unknown function. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in heart (RPKM 10.2), appendix (RPKM 7.2) and 25 other tissues See more
Orthologs

Genomic context

See ACOT9 in Genome Data Viewer
Location:
Xp22.11
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (23701055..23743290, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (23721777..23784592, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Hikeshi, heat shock protein nuclear import factor pseudogene Neighboring gene patched domain containing 1 Neighboring gene peroxiredoxin 4 Neighboring gene uncharacterized LOC105373148 Neighboring gene spermidine/spermine N1-acetyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Fatty Acyl-CoA Biosynthesis, organism-specific biosystem (from REACTOME)
    Fatty Acyl-CoA Biosynthesis, organism-specific biosystemFatty acyl-CoA biosynthesis involves following steps: -Palmitate synthesis catalyzed by Acetyl-CoA carboxylase and Fatty acid synthase-Conversion of palmitic acid to long chain fatty acids and-Conver...
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Triglyceride Biosynthesis, organism-specific biosystem (from REACTOME)
    Triglyceride Biosynthesis, organism-specific biosystemThe overall process of triglyceride (triacylglycerol) biosynthesis consists of four biochemical pathways: fatty acyl-CoA biosynthesis, conversion of fatty acyl-CoA to phosphatidic acid, conversion of...
  • acyl-CoA hydrolysis, organism-specific biosystem (from BIOCYC)
    acyl-CoA hydrolysis, organism-specific biosystem
    acyl-CoA hydrolysis

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acetyl-CoA hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acyl-CoA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acyl-CoA metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
acyl-coenzyme A thioesterase 9, mitochondrial
Names
acyl-CoA thioester hydrolase 9
acyl-Coenzyme A thioesterase 2, mitochondrial
mitochondrial Acyl-CoA Thioesterase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016780.2 RefSeqGene

    Range
    5001..44631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001033583.2NP_001028755.2  acyl-coenzyme A thioesterase 9, mitochondrial isoform b precursor

    See identical proteins and their annotated locations for NP_001028755.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK000659, AL548456, BX648512
    Consensus CDS
    CCDS35216.1
    UniProtKB/Swiss-Prot
    Q9Y305
    Related
    ENSP00000336580.7, ENST00000336430.11
    Conserved Domains (1) summary
    cd03442
    Location:286395
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
  2. NM_001037171.2NP_001032248.1  acyl-coenzyme A thioesterase 9, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_001032248.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC093011, AL548456, BX648512
    Consensus CDS
    CCDS43924.1
    UniProtKB/Swiss-Prot
    Q9Y305
    Related
    ENSP00000368605.5, ENST00000379303.10
    Conserved Domains (1) summary
    cd03442
    Location:295404
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
  3. NM_001330259.1NP_001317188.1  acyl-coenzyme A thioesterase 9, mitochondrial isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC093011, AC131011
    Consensus CDS
    CCDS83460.1
    UniProtKB/Swiss-Prot
    Q9Y305
    Related
    ENSP00000368597.1, ENST00000379295.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    23701055..23743290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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