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ORC3 origin recognition complex subunit 3 [ Homo sapiens (human) ]

Gene ID: 23595, updated on 24-Nov-2020

Summary

Official Symbol
ORC3provided by HGNC
Official Full Name
origin recognition complex subunit 3provided by HGNC
Primary source
HGNC:HGNC:8489
See related
Ensembl:ENSG00000135336 MIM:604972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAT; ORC3L; LATHEO
Summary
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 9.4), adrenal (RPKM 6.1) and 25 other tissues See more
Orthologs

Genomic context

See ORC3 in Genome Data Viewer
Location:
6q15
Exon count:
24
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (87590128..87677824)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (88299785..88377172)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member A1 Neighboring gene RNA, U6 small nuclear 444, pseudogene Neighboring gene arginyl-tRNA synthetase 2, mitochondrial Neighboring gene akirin 2 Neighboring gene uncharacterized LOC101928911 Neighboring gene FOXA motif-containing MPRA enhancer 167 Neighboring gene RNA, 7SL, cytoplasmic 183, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication TAS
Traceable Author Statement
more info
 
DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
pre-replicative complex assembly involved in nuclear cell cycle DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
DNA replication preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
chromosome, telomeric region HDA PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear origin of replication recognition complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pre-replicative complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
origin recognition complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
origin recognition complex subunit 3
Names
homolog of latheo, Drosophila
origin recognition complex subunit Latheo
origin recognition complex, subunit 3 honolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197259.2NP_001184188.1  origin recognition complex subunit 3 isoform 3

    See identical proteins and their annotated locations for NP_001184188.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region, resulting in a downstream AUG start codon, and also lacks three nts in an alternate splicing site in the 3' coding region, as compared to variant 1. The translation reading frame remains the same, and the resulting isoform (3) has a shorter N-terminus and lacks an internal aa, as compared to isoform 1.
    Source sequence(s)
    AK303195, BM971022, DC395106
    Consensus CDS
    CCDS56440.1
    UniProtKB/Swiss-Prot
    Q9UBD5
    Related
    ENSP00000444695.1, ENST00000546266.5
    Conserved Domains (1) summary
    pfam07034
    Location:1201
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
  2. NM_012381.4NP_036513.2  origin recognition complex subunit 3 isoform 2

    See identical proteins and their annotated locations for NP_036513.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three nts in an alternate splicing site in the 3' coding, as compared to variant 1. The translation reading frame remains the same, and the resulting isoform (2) lacks an internal aa, as compared to isoform 1.
    Source sequence(s)
    AF125507, BM971022
    Consensus CDS
    CCDS43486.1
    UniProtKB/Swiss-Prot
    Q9UBD5
    Related
    ENSP00000376586.3, ENST00000392844.7
    Conserved Domains (1) summary
    pfam07034
    Location:18344
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
  3. NM_181837.3NP_862820.1  origin recognition complex subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_862820.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC047689, BM971022, DC395106
    Consensus CDS
    CCDS5012.1
    UniProtKB/Swiss-Prot
    Q9UBD5
    Related
    ENSP00000257789.4, ENST00000257789.4
    Conserved Domains (1) summary
    pfam07034
    Location:41344
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    87590128..87677824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010632.2XP_016866121.1  origin recognition complex subunit 3 isoform X1

  2. XM_017010633.2XP_016866122.1  origin recognition complex subunit 3 isoform X2

  3. XM_005248704.2XP_005248761.1  origin recognition complex subunit 3 isoform X3

    Conserved Domains (1) summary
    pfam07034
    Location:18344
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
  4. XM_017010634.2XP_016866123.1  origin recognition complex subunit 3 isoform X4

  5. XM_011535651.2XP_011533953.1  origin recognition complex subunit 3 isoform X5

    Conserved Domains (1) summary
    pfam07034
    Location:18306
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
  6. XM_017010635.2XP_016866124.1  origin recognition complex subunit 3 isoform X6

  7. XM_011535652.3XP_011533954.1  origin recognition complex subunit 3 isoform X11

    Conserved Domains (1) summary
    pfam07034
    Location:18344
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
  8. XM_005248706.1XP_005248763.1  origin recognition complex subunit 3 isoform X7

    See identical proteins and their annotated locations for XP_005248763.1

    Conserved Domains (1) summary
    pfam07034
    Location:1291
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
  9. XM_017010639.1XP_016866128.1  origin recognition complex subunit 3 isoform X9

  10. XM_017010637.1XP_016866126.1  origin recognition complex subunit 3 isoform X8

  11. XM_017010640.1XP_016866129.1  origin recognition complex subunit 3 isoform X10

  12. XM_005248705.2XP_005248762.1  origin recognition complex subunit 3 isoform X7

    See identical proteins and their annotated locations for XP_005248762.1

    Conserved Domains (1) summary
    pfam07034
    Location:1291
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
  13. XM_017010638.2XP_016866127.1  origin recognition complex subunit 3 isoform X9

  14. XM_017010636.2XP_016866125.1  origin recognition complex subunit 3 isoform X8

RNA

  1. XR_001743294.2 RNA Sequence

  2. XR_001743295.2 RNA Sequence

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