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HEBP2 heme binding protein 2 [ Homo sapiens (human) ]

Gene ID: 23593, updated on 13-Mar-2020

Summary

Official Symbol
HEBP2provided by HGNC
Official Full Name
heme binding protein 2provided by HGNC
Primary source
HGNC:HGNC:15716
See related
Ensembl:ENSG00000051620 MIM:605825
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP23; SOUL; C6orf34; C6ORF34B
Summary
The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016]
Expression
Ubiquitous expression in fat (RPKM 80.4), prostate (RPKM 27.2) and 22 other tissues See more
Orthologs

Genomic context

See HEBP2 in Genome Data Viewer
Location:
6q24.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (138403531..138422197)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (138725336..138734582)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ARFGEF family member 3 Neighboring gene prostate and breast cancer overexpressed 1 Neighboring gene MARCKS like 1 pseudogene 2 Neighboring gene small integral membrane protein 28 Neighboring gene microRNA 3145 Neighboring gene NHS like 1 Neighboring gene mitochondrial carrier 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of heme binding protein 2 (HEBP2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of heme binding protein 2 (HEBP2; SOUL) in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1244

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heme-binding protein 2
Names
placental protein 23

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050594.1 RefSeqGene

    Range
    5025..22999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001326380.1NP_001313309.1  heme-binding protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL031003, AL391669
  2. NM_001326381.2NP_001313310.1  heme-binding protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL031003, AL391669
    Consensus CDS
    CCDS87448.1
    UniProtKB/TrEMBL
    Q5THN1
    Related
    ENSP00000356670.3, ENST00000367697.7
  3. NM_014320.3NP_055135.1  heme-binding protein 2 isoform 2

    See identical proteins and their annotated locations for NP_055135.1

    Status: REVIEWED

    Source sequence(s)
    AF117616, AK057928, AL391669, BF974311
    Consensus CDS
    CCDS5191.1
    UniProtKB/Swiss-Prot
    Q9Y5Z4
    Related
    ENSP00000475750.1, ENST00000607197.6
    Conserved Domains (1) summary
    pfam04832
    Location:36195
    SOUL; SOUL heme-binding protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    138403531..138422197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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