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FPR3 formyl peptide receptor 3 [ Homo sapiens (human) ]

Gene ID: 2359, updated on 4-Jun-2020

Summary

Official Symbol
FPR3provided by HGNC
Official Full Name
formyl peptide receptor 3provided by HGNC
Primary source
HGNC:HGNC:3828
See related
Ensembl:ENSG00000187474 MIM:136539
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FMLPY; FPRH1; FPRH2; FPRL2; RMLP-R-I; FMLP-R-II; FML2_HUMAN
Expression
Broad expression in appendix (RPKM 15.7), gall bladder (RPKM 12.8) and 22 other tissues See more
Orthologs

Genomic context

See FPR3 in Genome Data Viewer
Location:
19q13.41
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (51795157..51826207)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52298411..52329334)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene formyl peptide receptor 2 Neighboring gene uncharacterized LOC105372448 Neighboring gene zinc finger protein 577 Neighboring gene zinc finger protein 84 pseudogene Neighboring gene vomeronasal 1 receptor 98 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-formyl peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
complement receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
N-formyl peptide receptor 3
Names
FMLP-related receptor II
formyl peptide receptor-like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002030.5NP_002021.3  N-formyl peptide receptor 3

    See identical proteins and their annotated locations for NP_002021.3

    Status: VALIDATED

    Source sequence(s)
    AI301735, AK123030, BC059388, CB996360, DA844883
    Consensus CDS
    CCDS12841.1
    UniProtKB/Swiss-Prot
    P25089
    UniProtKB/TrEMBL
    Q6L5J4
    Related
    ENSP00000341821.3, ENST00000339223.5
    Conserved Domains (2) summary
    cd14964
    Location:2953
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27313
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    51795157..51826207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526687.2XP_011524989.1  N-formyl peptide receptor 3 isoform X1

    See identical proteins and their annotated locations for XP_011524989.1

    UniProtKB/Swiss-Prot
    P25089
    UniProtKB/TrEMBL
    Q6L5J4
    Related
    ENSP00000470471.1, ENST00000595991.1
    Conserved Domains (2) summary
    cd14964
    Location:2953
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27313
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
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