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CCNDBP1 cyclin D1 binding protein 1 [ Homo sapiens (human) ]

Gene ID: 23582, updated on 7-Jun-2020

Summary

Official Symbol
CCNDBP1provided by HGNC
Official Full Name
cyclin D1 binding protein 1provided by HGNC
Primary source
HGNC:HGNC:1587
See related
Ensembl:ENSG00000166946 MIM:607089
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HHM; DIP1; GCIP
Summary
This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009]
Expression
Ubiquitous expression in bone marrow (RPKM 23.1), placenta (RPKM 18.5) and 25 other tissues See more
Orthologs

Genomic context

See CCNDBP1 in Genome Data Viewer
Location:
15q15.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (43185118..43197177)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43477466..43489375)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene signal peptidase complex subunit 2 pseudogene 1 Neighboring gene transmembrane protein 62 Neighboring gene farnesyl diphosphate synthase pseudogene 10 Neighboring gene erythrocyte membrane protein band 4.2 Neighboring gene transglutaminase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cyclin-D1-binding protein 1
Names
D-type cyclin-interacting protein 1
cyclin D-type binding-protein 1
grap2 and cyclin-D-interacting protein
human homolog of Maid

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012142.5NP_036274.3  cyclin-D1-binding protein 1

    See identical proteins and their annotated locations for NP_036274.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the supported protein.
    Source sequence(s)
    AC068724, AF132034, AI953224, DA210890
    Consensus CDS
    CCDS10092.1
    UniProtKB/Swiss-Prot
    O95273
    Related
    ENSP00000300213.4, ENST00000300213.9
    Conserved Domains (1) summary
    pfam13324
    Location:55320
    GCIP; Grap2 and cyclin-D-interacting

RNA

  1. NR_027513.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in both the 5' and central regions, compared to variant 1. This variant is represented as non-coding because the use of the supported start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC068724, AF132034, AI953224, BI911845, DA210890
  2. NR_027514.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the supported start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC068724, AF132034, AI953224, AK295017, DA210890
  3. NR_045998.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the supported start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC068724, AI953224, AK290707, DA506028
  4. NR_045999.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two alternate exons in the 5' region and one alternate exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the supported start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC068724, AI953224, BQ439439, DA506028

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    43185118..43197177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720448.2XP_006720511.1  cyclin-D1-binding protein 1 isoform X1

    Conserved Domains (1) summary
    pfam13324
    Location:128364
    GCIP; Grap2 and cyclin-D-interacting
  2. XM_024449882.1XP_024305650.1  cyclin-D1-binding protein 1 isoform X2

    Conserved Domains (1) summary
    pfam13324
    Location:1159
    GCIP; Grap2 and cyclin-D-interacting

RNA

  1. XR_429445.2 RNA Sequence

    Related
    ENST00000563065.5
  2. XR_001751188.2 RNA Sequence

    Related
    ENST00000566515.5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_037370.2: Suppressed sequence

    Description
    NM_037370.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the 5' end of the transcript appears to be incompletely processed.
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