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CASP14 caspase 14 [ Homo sapiens (human) ]

Gene ID: 23581, updated on 9-May-2021

Summary

Official Symbol
CASP14provided by HGNC
Official Full Name
caspase 14provided by HGNC
Primary source
HGNC:HGNC:1502
See related
Ensembl:ENSG00000105141 MIM:605848
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARCI12
Summary
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward skin (RPKM 223.1) See more
Orthologs
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Genomic context

See CASP14 in Genome Data Viewer
Location:
19p13.12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (15049480..15058293)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15160291..15169104)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 1 member 6 Neighboring gene Sharpr-MPRA regulatory region 13248 Neighboring gene coiled-coil domain containing 105 Neighboring gene olfactory receptor family 1 subfamily I member 1 Neighboring gene synapse defective Rho GTPase homolog 1 Neighboring gene ilvB acetolactate synthase like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119078, MGC119079

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cornification TAS
Traceable Author Statement
more info
PubMed 
involved_in epidermis development TAS
Traceable Author Statement
more info
PubMed 
involved_in execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
 
involved_in keratinization TAS
Traceable Author Statement
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
caspase-14
Names
CASP-14
apoptosis-related cysteine protease
caspase 14, apoptosis-related cysteine peptidase
caspase 14, apoptosis-related cysteine protease
NP_036246.1
XP_011526163.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012114.3NP_036246.1  caspase-14 precursor

    See identical proteins and their annotated locations for NP_036246.1

    Status: REVIEWED

    Source sequence(s)
    AC004699, AK313992, BM840054
    Consensus CDS
    CCDS12323.1
    UniProtKB/Swiss-Prot
    P31944
    UniProtKB/TrEMBL
    B2CIS9
    Related
    ENSP00000393417.2, ENST00000427043.4
    Conserved Domains (1) summary
    cd00032
    Location:18242
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    15049480..15058293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527861.1XP_011526163.1  caspase-14 isoform X1

    See identical proteins and their annotated locations for XP_011526163.1

    Conserved Domains (1) summary
    cl00042
    Location:18181
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
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