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CDC42EP4 CDC42 effector protein 4 [ Homo sapiens (human) ]

Gene ID: 23580, updated on 13-Mar-2020

Summary

Official Symbol
CDC42EP4provided by HGNC
Official Full Name
CDC42 effector protein 4provided by HGNC
Primary source
HGNC:HGNC:17147
See related
Ensembl:ENSG00000179604 MIM:605468
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEP4; BORG4; KAIA1777
Summary
The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 35.1), brain (RPKM 34.5) and 25 other tissues See more
Orthologs

Genomic context

See CDC42EP4 in Genome Data Viewer
Location:
17q25.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (73283624..73312001, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (71279763..71308314, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 104 member A Neighboring gene component of oligomeric golgi complex 1 Neighboring gene chromosome 17 open reading frame 80 Neighboring gene cleavage and polyadenylation specific factor 4 like Neighboring gene Sharpr-MPRA regulatory region 4436 Neighboring gene sidekick cell adhesion molecule 2 Neighboring gene uncharacterized LOC101928251 Neighboring gene uncharacterized LOC107985091

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3740, MGC17125

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP-Rho binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP-Rho binding NAS
Non-traceable Author Statement
more info
PubMed 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of pseudopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of pseudopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cdc42 effector protein 4
Names
CDC42 effector protein (Rho GTPase binding) 4
binder of Rho GTPases 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012121.5NP_036253.2  cdc42 effector protein 4

    See identical proteins and their annotated locations for NP_036253.2

    Status: REVIEWED

    Source sequence(s)
    BC002774, BC010451, BI560730
    Consensus CDS
    CCDS11695.1
    UniProtKB/Swiss-Prot
    Q9H3Q1
    UniProtKB/TrEMBL
    B2R6D8
    Related
    ENSP00000338258.3, ENST00000335793.4
    Conserved Domains (2) summary
    pfam00786
    Location:2668
    PBD; P21-Rho-binding domain
    pfam14957
    Location:112228
    BORG_CEP; Cdc42 effector

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    73283624..73312001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257182.2XP_005257239.1  cdc42 effector protein 4 isoform X1

    See identical proteins and their annotated locations for XP_005257239.1

    UniProtKB/Swiss-Prot
    Q9H3Q1
    UniProtKB/TrEMBL
    B2R6D8
    Conserved Domains (2) summary
    pfam00786
    Location:2668
    PBD; P21-Rho-binding domain
    pfam14957
    Location:112228
    BORG_CEP; Cdc42 effector
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