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LPAR3 lysophosphatidic acid receptor 3 [ Homo sapiens (human) ]

Gene ID: 23566, updated on 13-Mar-2020

Summary

Official Symbol
LPAR3provided by HGNC
Official Full Name
lysophosphatidic acid receptor 3provided by HGNC
Primary source
HGNC:HGNC:14298
See related
Ensembl:ENSG00000171517 MIM:605106
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDG7; GPCR; LPA3; Edg-7; LP-A3; HOFNH30; RP4-678I3
Summary
This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 8.7), testis (RPKM 8.1) and 12 other tissues See more
Orthologs

Genomic context

See LPAR3 in Genome Data Viewer
Location:
1p22.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (84811601..84893206, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (85279086..85358896, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SSX family member 2 interacting protein Neighboring gene uncharacterized LOC102724892 Neighboring gene mucolipin 2 Neighboring gene mucolipin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.
NHGRI GWA Catalog
Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
NHGRI GWA Catalog
Genome-wide association study of smoking behaviours among Bangladeshi adults.
NHGRI GWA Catalog
GWAS of dental caries patterns in the permanent dentition.
NHGRI GWA Catalog
The genetic architecture of economic and political preferences.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of lysophosphatidic acid receptor 3 (LPAR3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ98231

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
G-protein alpha-subunit binding IEA
Inferred from Electronic Annotation
more info
 
lipid binding TAS
Traceable Author Statement
more info
PubMed 
lysophosphatidic acid receptor activity IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lysophosphatidic acid receptor 3
Names
LPA receptor 3
LPA receptor EDG7
LPA-3
calcium-mobilizing lysophosphatidic acid receptor LP-A3
endothelial cell differentiation gene 7
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7
lysophosphatidic acid receptor Edg-7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012152.3NP_036284.1  lysophosphatidic acid receptor 3

    See identical proteins and their annotated locations for NP_036284.1

    Status: REVIEWED

    Source sequence(s)
    AC104169, AK308283, BC126268, BU633960
    Consensus CDS
    CCDS700.1
    UniProtKB/Swiss-Prot
    Q9UBY5
    Related
    ENSP00000359643.3, ENST00000370611.4
    Conserved Domains (1) summary
    cd15343
    Location:31304
    7tmA_LPAR3_Edg7; lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    84811601..84893206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446127.1XP_024301895.1  lysophosphatidic acid receptor 3 isoform X1

    Conserved Domains (1) summary
    cd15343
    Location:42315
    7tmA_LPAR3_Edg7; lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_024446128.1XP_024301896.1  lysophosphatidic acid receptor 3 isoform X2

    Related
    ENSP00000395389.1, ENST00000440886.1
    Conserved Domains (1) summary
    cd15343
    Location:31304
    7tmA_LPAR3_Edg7; lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors
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