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GTPBP4 GTP binding protein 4 [ Homo sapiens (human) ]

Gene ID: 23560, updated on 13-Mar-2020

Summary

Official Symbol
GTPBP4provided by HGNC
Official Full Name
GTP binding protein 4provided by HGNC
Primary source
HGNC:HGNC:21535
See related
Ensembl:ENSG00000107937
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NGB; CRFG; NOG1
Summary
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 19.5), testis (RPKM 18.5) and 25 other tissues See more
Orthologs

Genomic context

See GTPBP4 in Genome Data Viewer
Location:
10p15.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (988434..1019932)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (1034349..1063708)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984285 Neighboring gene uncharacterized LOC105376341 Neighboring gene Sharpr-MPRA regulatory region 2332 Neighboring gene IDI2 antisense RNA 1 Neighboring gene isopentenyl-diphosphate delta isomerase 2 Neighboring gene isopentenyl-diphosphate delta isomerase 1 Neighboring gene WD repeat domain 37

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of GTP binding protein 4 (GTPBP4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10686, FLJ10690, FLJ39774

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nucleolar GTP-binding protein 1
Names
G protein-binding protein CRFG
GTP-binding protein NGB
chronic renal failure gene protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012341.3NP_036473.2  nucleolar GTP-binding protein 1

    See identical proteins and their annotated locations for NP_036473.2

    Status: REVIEWED

    Source sequence(s)
    AC022536, AL359878
    Consensus CDS
    CCDS31132.1
    UniProtKB/Swiss-Prot
    Q9BZE4
    UniProtKB/TrEMBL
    D2CFK9
    Related
    ENSP00000354040.4, ENST00000360803.9
    Conserved Domains (2) summary
    COG1084
    Location:5345
    Nog1; GTP-binding protein, GTP1/Obg family [General function prediction only]
    pfam08155
    Location:396446
    NOGCT; NOGCT (NUC087) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    988434..1019932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447921.1XP_024303689.1  nucleolar GTP-binding protein 1 isoform X1

    Conserved Domains (2) summary
    cd01897
    Location:1131
    NOG; Nucleolar GTP-binding protein (NOG)
    pfam08155
    Location:187237
    NOGCT; NOGCT (NUC087) domain
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