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TSPAN12 tetraspanin 12 [ Homo sapiens (human) ]

Gene ID: 23554, updated on 22-Sep-2022

Summary

Official Symbol
TSPAN12provided by HGNC
Official Full Name
tetraspanin 12provided by HGNC
Primary source
HGNC:HGNC:21641
See related
Ensembl:ENSG00000106025 MIM:613138; AllianceGenome:HGNC:21641
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EVR5; NET2; NET-2; TM4SF12
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 32.8), adrenal (RPKM 28.5) and 21 other tissues See more
Orthologs
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Genomic context

See TSPAN12 in Genome Data Viewer
Location:
7q31.31
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (120787320..120858335, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (122102649..122173489, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (120427374..120498198, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375477 Neighboring gene potassium voltage-gated channel subfamily D member 2 Neighboring gene RNA, U6 small nuclear 581, pseudogene Neighboring gene Sharpr-MPRA regulatory region 15278 Neighboring gene uncharacterized LOC124901733 Neighboring gene uncharacterized LOC124901734 Neighboring gene RNA, 5S ribosomal pseudogene 240 Neighboring gene inhibitor of growth family member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables Wnt receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of vascular endothelial growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retina layer formation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
tetraspanin-12
Names
tetraspan NET-2
transmembrane 4 superfamily member 12
tspan-12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023203.1 RefSeqGene

    Range
    4980..75804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012338.4NP_036470.1  tetraspanin-12

    See identical proteins and their annotated locations for NP_036470.1

    Status: REVIEWED

    Source sequence(s)
    AC004456, AY358703, BF338835, BI964728
    Consensus CDS
    CCDS5777.1
    UniProtKB/Swiss-Prot
    O95859, Q8N5Y0
    UniProtKB/TrEMBL
    A0A024R740
    Related
    ENSP00000222747.3, ENST00000222747.8
    Conserved Domains (2) summary
    cd03157
    Location:116218
    TM4SF12_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10244
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    120787320..120858335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420096.1XP_047276052.1  tetraspanin-12 isoform X2

  2. XM_005250239.4XP_005250296.1  tetraspanin-12 isoform X1

    See identical proteins and their annotated locations for XP_005250296.1

    UniProtKB/Swiss-Prot
    O95859, Q8N5Y0
    UniProtKB/TrEMBL
    A0A024R740
    Conserved Domains (2) summary
    cd03157
    Location:116218
    TM4SF12_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10244
    Tetraspannin; Tetraspanin family
  3. XM_047420095.1XP_047276051.1  tetraspanin-12 isoform X1

    UniProtKB/Swiss-Prot
    Q8N5Y0
    UniProtKB/TrEMBL
    A0A024R740
    Related
    ENSP00000397699.1, ENST00000415871.5
  4. XM_047420097.1XP_047276053.1  tetraspanin-12 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    122102649..122173489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)