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HYAL4 hyaluronidase 4 [ Homo sapiens (human) ]

Gene ID: 23553, updated on 11-Jun-2021

Summary

Official Symbol
HYAL4provided by HGNC
Official Full Name
hyaluronidase 4provided by HGNC
Primary source
HGNC:HGNC:5323
See related
Ensembl:ENSG00000106302 MIM:604510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSHY; HYAL-4
Summary
This gene encodes a protein which is similar in structure to hyaluronidases but lacks hyaluronidase activity. The encoded protein acts as a chondroitin-sulfate-specific endo-beta-N-acetylgalactosaminidase; that is, it exhibits hydrolytic activity toward chondroitin sulfate chains and degrades them into oligosaccharides. Proteoglycans are formed by the covalent linkage of chondroitin sulfate chains to protein. Proteoglycans are ubiquitous components of the extracellular matrix of connective tissues and are also found at the surface of many cell types where they participate in a variety of cellular processes such as cell proliferation, differentiation, migration, cell-cell recognition, extracellular matrix deposition, and tissue morphogenesis. The expression of this gene is highest in testes and placenta. [provided by RefSeq, Apr 2019]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See HYAL4 in Genome Data Viewer
Location:
7q31.32
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (123763708..123877481)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (123485223..123517535)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene WASP like actin nucleation promoting factor Neighboring gene WASL divergent transcript Neighboring gene RNA, U6 small nuclear 11, pseudogene Neighboring gene hyaluronidase 6, pseudogene Neighboring gene sperm adhesion molecule 1 Neighboring gene uncharacterized LOC105375483

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hyalurononglucosaminidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in chondroitin sulfate catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycosaminoglycan catabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in hyaluronan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hyaluronidase-4
Names
HYAL-4 variant 1
chondroitin sulfate endo-beta-N-acetylgalactosaminidase
chondroitin sulfate hydrolase
hyaluronoglucosaminidase 4
NP_036401.2
XP_011514292.1
XP_016867400.1
XP_024302471.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012269.3NP_036401.2  hyaluronidase-4

    See identical proteins and their annotated locations for NP_036401.2

    Status: REVIEWED

    Source sequence(s)
    AC006029, AF009010, BC104788, BF085228, BG013757
    Consensus CDS
    CCDS5789.1
    UniProtKB/Swiss-Prot
    Q2M3T9
    Related
    ENSP00000223026.4, ENST00000223026.9
    Conserved Domains (1) summary
    pfam01630
    Location:41369
    Glyco_hydro_56; Hyaluronidase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    123763708..123877481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011911.1XP_016867400.1  hyaluronidase-4 isoform X1

    UniProtKB/Swiss-Prot
    Q2M3T9
    Conserved Domains (1) summary
    pfam01630
    Location:41369
    Glyco_hydro_56; Hyaluronidase
  2. XM_011515990.2XP_011514292.1  hyaluronidase-4 isoform X1

    See identical proteins and their annotated locations for XP_011514292.1

    UniProtKB/Swiss-Prot
    Q2M3T9
    Conserved Domains (1) summary
    pfam01630
    Location:41369
    Glyco_hydro_56; Hyaluronidase
  3. XM_024446703.1XP_024302471.1  hyaluronidase-4 isoform X2

    Conserved Domains (1) summary
    pfam01630
    Location:41339
    Glyco_hydro_56; Hyaluronidase

RNA

  1. XR_002956416.1 RNA Sequence

    Related
    ENST00000483878.1
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