U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HYAL4 hyaluronidase 4 [ Homo sapiens (human) ]

Gene ID: 23553, updated on 23-Nov-2023

Summary

Official Symbol
HYAL4provided by HGNC
Official Full Name
hyaluronidase 4provided by HGNC
Primary source
HGNC:HGNC:5323
See related
Ensembl:ENSG00000106302 MIM:604510; AllianceGenome:HGNC:5323
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSHY; HYAL-4
Summary
This gene encodes a protein which is similar in structure to hyaluronidases but lacks hyaluronidase activity. The encoded protein acts as a chondroitin-sulfate-specific endo-beta-N-acetylgalactosaminidase; that is, it exhibits hydrolytic activity toward chondroitin sulfate chains and degrades them into oligosaccharides. Proteoglycans are formed by the covalent linkage of chondroitin sulfate chains to protein. Proteoglycans are ubiquitous components of the extracellular matrix of connective tissues and are also found at the surface of many cell types where they participate in a variety of cellular processes such as cell proliferation, differentiation, migration, cell-cell recognition, extracellular matrix deposition, and tissue morphogenesis. The expression of this gene is highest in testes and placenta. [provided by RefSeq, Apr 2019]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See HYAL4 in Genome Data Viewer
Location:
7q31.32
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (123763708..123877481)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (125161887..125194214)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (123485223..123517535)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:123332146-123332646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:123332647-123333147 Neighboring gene WASP like actin nucleation promoting factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18587 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:123388787-123389441 Neighboring gene WASL divergent transcript Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:123438019-123438540 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:123438541-123439062 Neighboring gene RNA, U6 small nuclear 11, pseudogene Neighboring gene hyaluronidase 6, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:123534015-123535214 Neighboring gene COX6A1 pseudogene 6 Neighboring gene sperm adhesion molecule 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:123634231-123635109 Neighboring gene uncharacterized LOC105375483

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hyalurononglucosaminidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in chondroitin sulfate catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycosaminoglycan catabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in hyaluronan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hyaluronidase-4
Names
chondroitin sulfate endo-beta-N-acetylgalactosaminidase
chondroitin sulfate hydrolase
hyaluronoglucosaminidase 4
NP_036401.2
XP_011514292.1
XP_024302471.1
XP_047276049.1
XP_047276050.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012269.3NP_036401.2  hyaluronidase-4

    See identical proteins and their annotated locations for NP_036401.2

    Status: REVIEWED

    Source sequence(s)
    AC006029, AF009010, BC104788, BF085228, BG013757
    Consensus CDS
    CCDS5789.1
    UniProtKB/Swiss-Prot
    D0VXG1, Q2M3T9, Q9UL99, Q9Y6T9
    Related
    ENSP00000223026.4, ENST00000223026.9
    Conserved Domains (1) summary
    pfam01630
    Location:41369
    Glyco_hydro_56; Hyaluronidase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    123763708..123877481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420093.1XP_047276049.1  hyaluronidase-4 isoform X1

    UniProtKB/Swiss-Prot
    D0VXG1, Q2M3T9, Q9UL99, Q9Y6T9
  2. XM_011515990.2XP_011514292.1  hyaluronidase-4 isoform X1

    See identical proteins and their annotated locations for XP_011514292.1

    UniProtKB/Swiss-Prot
    D0VXG1, Q2M3T9, Q9UL99, Q9Y6T9
    Conserved Domains (1) summary
    pfam01630
    Location:41369
    Glyco_hydro_56; Hyaluronidase
  3. XM_047420094.1XP_047276050.1  hyaluronidase-4 isoform X1

    UniProtKB/Swiss-Prot
    D0VXG1, Q2M3T9, Q9UL99, Q9Y6T9
    Related
    ENSP00000417186.1, ENST00000476325.5
  4. XM_024446703.1XP_024302471.1  hyaluronidase-4 isoform X2

    Conserved Domains (1) summary
    pfam01630
    Location:41339
    Glyco_hydro_56; Hyaluronidase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    125161887..125194214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)