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RASD2 RASD family member 2 [ Homo sapiens (human) ]

Gene ID: 23551, updated on 5-Jul-2025
Official Symbol
RASD2provided by HGNC
Official Full Name
RASD family member 2provided by HGNC
Primary source
HGNC:HGNC:18229
See related
Ensembl:ENSG00000100302 MIM:612842; AllianceGenome:HGNC:18229
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Rhes; TEM2
Summary
This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016]
Expression
Broad expression in prostate (RPKM 3.2), brain (RPKM 2.7) and 18 other tissues See more
Orthologs
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See RASD2 in Genome Data Viewer
Location:
22q12.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (35532806..35553999)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (35991542..36012893)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (35928853..35950046)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18908 Neighboring gene minichromosome maintenance complex component 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:35821835-35822340 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:35822341-35822848 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:35822849-35823354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:35831135-35831636 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18909 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:35844065-35845031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:35845032-35845997 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:35874918-35875095 Neighboring gene tRNA methyltransferase subunit 11-2 pseudogene 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:35935540-35936102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:35936103-35936665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:35936666-35937228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:35945090-35945800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:35948337-35949316 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:35957537-35958268 Neighboring gene uncharacterized LOC107985590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:35976583-35977082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:35979057-35979558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:35985272-35986247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:35987987-35988548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:35994347-35995088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:36001614-36002114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13659 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:36018115-36018630 Neighboring gene Sharpr-MPRA regulatory region 11360 Neighboring gene myoglobin

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G-protein beta-subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein sumoylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
GTP-binding protein Rhes
Names
Ras homolog enriched in striatum
tumor endothelial marker 2
NP_001353654.1
NP_001363444.1
NP_001363445.1
NP_055125.2
XP_011528342.1
XP_016884191.1
XP_054181372.1
XP_054181373.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366725.1NP_001353654.1  GTP-binding protein Rhes precursor

    Status: REVIEWED

    Source sequence(s)
    AL022334
    Consensus CDS
    CCDS13916.1
    UniProtKB/Swiss-Prot
    O95520, Q5THY8, Q96D21
    Conserved Domains (1) summary
    cd04143
    Location:20266
    Rhes_like; Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)
  2. NM_001376515.1NP_001363444.1  GTP-binding protein Rhes precursor

    Status: REVIEWED

    Source sequence(s)
    AL022334
    Consensus CDS
    CCDS13916.1
    UniProtKB/Swiss-Prot
    O95520, Q5THY8, Q96D21
    Conserved Domains (1) summary
    cd04143
    Location:20266
    Rhes_like; Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)
  3. NM_001376516.1NP_001363445.1  GTP-binding protein Rhes precursor

    Status: REVIEWED

    Source sequence(s)
    AL022334
    Consensus CDS
    CCDS13916.1
    UniProtKB/Swiss-Prot
    O95520, Q5THY8, Q96D21
    Conserved Domains (1) summary
    cd04143
    Location:20266
    Rhes_like; Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)
  4. NM_014310.4NP_055125.2  GTP-binding protein Rhes precursor

    See identical proteins and their annotated locations for NP_055125.2

    Status: REVIEWED

    Source sequence(s)
    AL022334, BC013419
    Consensus CDS
    CCDS13916.1
    UniProtKB/Swiss-Prot
    O95520, Q5THY8, Q96D21
    Related
    ENSP00000216127.4, ENST00000216127.5
    Conserved Domains (1) summary
    cd04143
    Location:20266
    Rhes_like; Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    35532806..35553999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028702.2XP_016884191.1  GTP-binding protein Rhes isoform X1

    UniProtKB/Swiss-Prot
    O95520, Q5THY8, Q96D21
    Conserved Domains (1) summary
    cd04143
    Location:20266
    Rhes_like; Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)
  2. XM_011530040.3XP_011528342.1  GTP-binding protein Rhes isoform X1

    See identical proteins and their annotated locations for XP_011528342.1

    UniProtKB/Swiss-Prot
    O95520, Q5THY8, Q96D21
    Conserved Domains (1) summary
    cd04143
    Location:20266
    Rhes_like; Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    35991542..36012893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325397.1XP_054181372.1  GTP-binding protein Rhes isoform X1

    UniProtKB/Swiss-Prot
    O95520, Q5THY8, Q96D21
  2. XM_054325398.1XP_054181373.1  GTP-binding protein Rhes isoform X1

    UniProtKB/Swiss-Prot
    O95520, Q5THY8, Q96D21