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Cd109 CD109 antigen [ Mus musculus (house mouse) ]

Gene ID: 235505, updated on 4-Jun-2024

Summary

Official Symbol
Cd109provided by MGI
Official Full Name
CD109 antigenprovided by MGI
Primary source
MGI:MGI:2445221
See related
Ensembl:ENSMUSG00000046186 AllianceGenome:MGI:2445221
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GARP; 9930012E15Rik
Summary
Predicted to enable transforming growth factor beta binding activity. Acts upstream of or within several processes, including negative regulation of keratinocyte proliferation; osteoclast fusion; and regulation of keratinocyte differentiation. Located in extracellular space. Is expressed in brain. Orthologous to human CD109 (CD109 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 3.2), testis adult (RPKM 3.0) and 15 other tissues See more
Orthologs
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Genomic context

See Cd109 in Genome Data Viewer
Location:
9 E1; 9 43.65 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (78522828..78623542)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (78615546..78716260)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24732 Neighboring gene STARR-seq mESC enhancer starr_24733 Neighboring gene predicted gene, 53210 Neighboring gene STARR-seq mESC enhancer starr_24735 Neighboring gene STARR-seq mESC enhancer starr_24737 Neighboring gene solute carrier family 17 (anion/sugar transporter), member 5 Neighboring gene STARR-positive B cell enhancer ABC_E3847 Neighboring gene STARR-positive B cell enhancer mm9_chr9:78444699-78445000 Neighboring gene STARR-seq mESC enhancer starr_24739 Neighboring gene STARR-positive B cell enhancer mm9_chr9:78548450-78548751 Neighboring gene STARR-seq mESC enhancer starr_24741 Neighboring gene STARR-seq mESC enhancer starr_24742 Neighboring gene predicted gene, 46138 Neighboring gene predicted gene, 39376

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CD109 antigen
Names
GPI-anchored alpha 2 macroglobulin-related protein
Gov platelet alloantigens

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153098.3NP_694738.1  CD109 antigen precursor

    See identical proteins and their annotated locations for NP_694738.1

    Status: VALIDATED

    Source sequence(s)
    AI850351, DQ832284
    Consensus CDS
    CCDS23365.1
    UniProtKB/Swiss-Prot
    Q8BLT6, Q8R422
    UniProtKB/TrEMBL
    A6MDD3
    Related
    ENSMUSP00000091330.5, ENSMUST00000093812.5
    Conserved Domains (7) summary
    COG2373
    Location:1221002
    YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
    cd02897
    Location:9091195
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:695782
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:129220
    A2M_N; MG2 domain
    pfam07677
    Location:13111395
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:9611197
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:475598
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    78522828..78623542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)